Universität zu Köln

Heidel, Andrew J., Lawal, Hajara M., Felder, Marius, Schilde, Christina, Helps, Nicholas R., Tunggal, Budi, Rivero, Francisco ORCID: 0000-0001-5435-6991, John, Uwe, Schleicher, Michael, Eichinger, Ludwig ORCID: 0000-0003-1594-6117, Platzer, Matthias, Noegel, Angelika A., Schaap, Pauline ORCID: 0000-0003-4500-2555 and Gloeckner, Gernot (2011). Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication. Genome Res., 21 (11). S. 1882 - 1892. COLD SPRING HARBOR: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT. ISSN 1549-5469

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Abstract

Dictyostelium discoideum (DD), an extensively studied model organism for cell and developmental biology, belongs to the most derived group 4 of social amoebas, a clade of altruistic multicellular organisms. To understand genome evolution over long time periods and the genetic basis of social evolution, we sequenced the genomes of Dictyostelium fasciculatum (DF) and Polysphondylium pallidum (PP), which represent the early diverging groups 1 and 2, respectively. In contrast to DD, PP and DF have conventional telomere organization and strongly reduced numbers of transposable elements. The number of protein-coding genes is similar between species, but only half of them comprise an identifiable set of orthologous genes. In general, genes involved in primary metabolism, cytoskeletal functions and signal transduction are conserved, while genes involved in secondary metabolism, export, and signal perception underwent large differential gene family expansions. This most likely signifies involvement of the conserved set in core cell and developmental mechanisms, and of the diverged set in niche-and species-specific adaptations for defense and food, mate, and kin selection. Phylogenetic dating using a concatenated data set and extensive loss of synteny indicate that DF, PP, and DD split from their last common ancestor at least 0.6 billion years ago.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heidel, Andrew J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lawal, Hajara M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Felder, Marius UNSPECIFIED UNSPECIFIED UNSPECIFIED Schilde, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Helps, Nicholas R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tunggal, Budi UNSPECIFIED UNSPECIFIED UNSPECIFIED Rivero, Francisco UNSPECIFIED orcid.org/0000-0001-5435-6991 UNSPECIFIED John, Uwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Schleicher, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichinger, Ludwig UNSPECIFIED orcid.org/0000-0003-1594-6117 UNSPECIFIED Platzer, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Noegel, Angelika A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaap, Pauline UNSPECIFIED orcid.org/0000-0003-4500-2555 UNSPECIFIED Gloeckner, Gernot UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-486615
DOI:	10.1101/gr.121137.111
Journal or Publication Title:	Genome Res.
Volume:	21
Number:	11
Page Range:	S. 1882 - 1892
Date:	2011
Publisher:	COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Place of Publication:	COLD SPRING HARBOR
ISSN:	1549-5469
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DICTYOSTELIUM-DISCOIDEUM; POLYKETIDE SYNTHASE; TERMINAL DIFFERENTIATION; RNA GENES; EVOLUTION; SEQUENCE; CAMP; IDENTIFICATION; BIOSYNTHESIS; PROGRAM Multiple languages Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48661