Universität zu Köln

Vossel, Simone ORCID: 0000-0002-6351-8849, Warbrick, Tracy ORCID: 0000-0001-8619-9409, Mobascher, Arian, Winterer, Georg and Fink, Gereon R. ORCID: 0000-0002-8230-1856 (2011). Spatial and sustained attention in relation to smoking status: behavioural performance and brain activation patterns. J. Psychopharmacol., 25 (11). S. 1485 - 1496. LONDON: SAGE PUBLICATIONS LTD. ISSN 0269-8811

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Abstract

Nicotine enhances attentional functions. Since chronic nicotine exposure through smoking induces neuroadaptive changes in the brain at a structural and molecular level, the present functional MRI (fMRI) study aimed at investigating the neural mechanisms underlying visuospatial and sustained attention in smokers and non-smokers. Visuospatial attention was assessed with a location-cueing paradigm, while sustained attention was measured by changes in response speed over time. During invalid trials, neural activity within the basal forebrain was selectively enhanced in smokers and higher basal forebrain activity was associated with increased parietal cortex activation. Moreover, higher levels of expired carbon monoxide in smokers before scanning were associated with higher parietal cortex activation and faster responses to invalidly cued targets. Smokers showed a slowing of responses and additionally recruited an area within the right supramarginal gyrus with increasing time on task. Activity decreases over time were observed in visual areas in smokers. The data provide evidence for altered attentional functions in smokers as compared with non-smokers, which were partly modulated by residual nicotine levels and were observed at a behavioural level for sustained and at a neural level for spatial and sustained attention.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vossel, Simone UNSPECIFIED orcid.org/0000-0002-6351-8849 UNSPECIFIED Warbrick, Tracy UNSPECIFIED orcid.org/0000-0001-8619-9409 UNSPECIFIED Mobascher, Arian UNSPECIFIED UNSPECIFIED UNSPECIFIED Winterer, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-486714
DOI:	10.1177/0269881110391830
Journal or Publication Title:	J. Psychopharmacol.
Volume:	25
Number:	11
Page Range:	S. 1485 - 1496
Date:	2011
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	0269-8811
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CUED TARGET DETECTION; HUMAN TOBACCO SMOKERS; BASAL FOREBRAIN; VISUOSPATIAL ATTENTION; COGNITIVE PERFORMANCE; CIGARETTE-SMOKING; PARIETAL CORTEX; TOP-DOWN; NICOTINE; ABSTINENCE Multiple languages Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48671