Universität zu Köln

Marbacher, Serge ORCID: 0000-0001-6305-7571, Milavec, Helena ORCID: 0000-0002-5689-0095, Neuschmelting, Volker ORCID: 0000-0001-7527-6990, Andereggen, Lukas ORCID: 0000-0003-1764-688X, Erhardt, Salome and Fandino, Javier (2011). Outer skull landmark-based coordinates for measurement of cerebral blood flow and intracranial pressure in rabbits. J. Neurosci. Methods, 201 (2). S. 322 - 327. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 0165-0270

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Abstract

Despite the increased use of intracranial neuromonitoring during experimental subarachnoid hemorrhage (SAH), coordinates for probe placement in rabbits are lacking. This study evaluates the safety and reliability of using outer skull landmarks to identify locations for placement of cerebral blood flow (CBF) and intraparenchymal intracranial pressure (ICP) probes. Experimental SAH was performed in 17 rabbits using an extracranial-intracranial shunt model. ICP probes were placed in the frontal lobe and compared to measurements recorded from the olfactory bulb. CBF probes were placed in various locations in the frontal cortex anterior to the coronary suture. Insertion depth, relation to the ventricular system, and ideal placement location were determined by post-mortem examination. ICP recordings at the time of SAH from the frontal lobe did not differ significantly from those obtained from the right olfactory bulb. Ideal coordinates for intraparenchymal CBF probes in the left and right frontal lobe were found to be located 4.6 +/- 0.9 and 4.5 +/- 1.2 anterior to the bregma, 4.7 +/- 0.7 mm and 4.7 +/- 0.5 mm parasagittal, and at depths of 4 +/- 0.5 mm and 3.9 +/- 0.5 mm, respectively. The results demonstrate that the presented coordinates based on skull landmarks allow reliable placement of intraparenchymal ICP and CBF probes in rabbit brains without the use of a stereotactic frame. (C) 2011 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Marbacher, Serge UNSPECIFIED orcid.org/0000-0001-6305-7571 UNSPECIFIED Milavec, Helena UNSPECIFIED orcid.org/0000-0002-5689-0095 UNSPECIFIED Neuschmelting, Volker UNSPECIFIED orcid.org/0000-0001-7527-6990 UNSPECIFIED Andereggen, Lukas UNSPECIFIED orcid.org/0000-0003-1764-688X UNSPECIFIED Erhardt, Salome UNSPECIFIED UNSPECIFIED UNSPECIFIED Fandino, Javier UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-487238
DOI:	10.1016/j.jneumeth.2011.08.009
Journal or Publication Title:	J. Neurosci. Methods
Volume:	201
Number:	2
Page Range:	S. 322 - 327
Date:	2011
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	0165-0270
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUBARACHNOID HEMORRHAGE; HEAD HOLDER; STEREOTAXIC SURGERY; VASOSPASM; SYSTEM Multiple languages Biochemical Research Methods; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48723