Universität zu Köln

Piccolo, Giovanni, Tavazzi, Eleonora, Jarius, Sven, Alfonsi, Enrico, Cavagna, Lorenzo ORCID: 0000-0003-3292-1528, Piccolo, Laura, Zardini, Elisabetta, Voltz, Raymond and Franciotta, Diego ORCID: 0000-0002-3014-3913 (2011). Anti-Ma2/Ta antibodies in a woman with primary lateral sclerosis-like phenotype and Sjogren syndrome. Neurol. Sci., 32 (5). S. 915 - 918. NEW YORK: SPRINGER. ISSN 1590-1874

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Abstract

Anti-Ma2/Ta antibodies are rare paraneoplastic antibodies, which are mostly associated with limbic encephalitis in male patients with testicular cancer. We report on a 50-year-old woman with a pure progressive spastic paraparesis. Next, she was diagnosed as having a Sjogren syndrome, with serological positivity for anti-SS-Ro antibodies. The patient's serum and cerebrospinal fluid samples were positive for anti-Ma2/Ta antibodies, which were also proved to be intrathecally produced. These findings, and the coexistence of systemic autoimmunity, led us to treat the patient with corticosteroids first, and then with plasma exchange. Neurological symptoms scarcely responded to both the therapies. The search for cancer was negative up to 4 years after the disease onset. Our case expands the spectrum of clinical syndromes associated with anti-Ma2/Ta antibodies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Piccolo, Giovanni UNSPECIFIED UNSPECIFIED UNSPECIFIED Tavazzi, Eleonora UNSPECIFIED UNSPECIFIED UNSPECIFIED Jarius, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Alfonsi, Enrico UNSPECIFIED UNSPECIFIED UNSPECIFIED Cavagna, Lorenzo UNSPECIFIED orcid.org/0000-0003-3292-1528 UNSPECIFIED Piccolo, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Zardini, Elisabetta UNSPECIFIED UNSPECIFIED UNSPECIFIED Voltz, Raymond UNSPECIFIED UNSPECIFIED UNSPECIFIED Franciotta, Diego UNSPECIFIED orcid.org/0000-0002-3014-3913 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-487578
DOI:	10.1007/s10072-011-0510-y
Journal or Publication Title:	Neurol. Sci.
Volume:	32
Number:	5
Page Range:	S. 915 - 918
Date:	2011
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1590-1874
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PARANEOPLASTIC NEUROLOGICAL SYNDROMES; ANTINEURONAL ANTIBODIES; DIAGNOSTIC-CRITERIA; MANIFESTATIONS; ENCEPHALITIS; BRAIN Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48757