Universität zu Köln

Preuss, S. F., Klussmann, J. -P., Semrau, R. and Huebbers, C. (2011). Update on HPV-induced oropharyngeal cancer. HNO, 59 (10). S. 1031 - 1038. NEW YORK: SPRINGER. ISSN 0017-6192

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Abstract

Oropharyngeal squamous cell carcinoma (OSCC) is associated with oncogenic human papillomavirus (HPV) infection in 30-40% of all cases in Germany. The use of PCR and/or in situ hybridisation to detect HPV in tumour tissue is used in combination with p16 immunohistochemistry to reliably distinguish HPV-related and HPV-unrelated OSCC. The distinct biological behaviour of the HPV-related subset of OSCC results in a more favourable prognosis. This might be the result of a greater response to chemotherapy and radiotherapy as seen in recent studies. Ongoing and future clinical trials will stratify for HPV status. If the results of these prospective, randomized trials are consistent with the preliminary results of recent studies, HPV status will be of enormous clinical relevance in the future.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Preuss, S. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klussmann, J. -P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Semrau, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Huebbers, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-487672
DOI:	10.1007/s00106-011-2391-z
Journal or Publication Title:	HNO
Volume:	59
Number:	10
Page Range:	S. 1031 - 1038
Date:	2011
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	0017-6192
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN-PAPILLOMAVIRUS INFECTION; NECK-CANCER; RISK-FACTOR; HEAD; CARCINOMA; PROGNOSIS; SURVIVAL Multiple languages Otorhinolaryngology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48767