Universität zu Köln

Kuhn, Jens, Gruendler, Theo O. J., Bauer, Robert, Huff, Wolfgang, Fischer, Adrian G., Lenartz, Doris, Maarouf, Mohammad, Buehrle, Christian, Klosterkoetter, Joachim, Ullsperger, Markus ORCID: 0000-0003-3970-1982 and Sturm, Volker (2011). Successful deep brain stimulation of the nucleus accumbens in severe alcohol dependence is associated with changed performance monitoring. Addict. Biol., 16 (4). S. 620 - 624. MALDEN: WILEY-BLACKWELL. ISSN 1355-6215

Full text not available from this repository.

Abstract

Following recent advances in neuromodulation therapy for mental disorders, we treated one patient with severe alcohol addiction with deep brain stimulation (DBS) of the nucleus accumbens (NAc). Before and one year following the surgery, we assessed the effects of DBS within the NAc on the addiction as well as on psychometric scores and electrophysiological measures of cognitive control. In our patient, DBS achieved normalization of addictive behavior and craving. An electrophysiological marker of error processing (the error-related negativity) linked to anterior midcingulate cortex (aMCC) functioning was altered through DBS, an effect that could be reversed by periods without stimulation. Thus, this case supports the hypothesis that DBS of the NAc could have a positive effect on addiction trough a normalization of craving associated with aMCC dysfunction.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kuhn, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruendler, Theo O. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Huff, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Adrian G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lenartz, Doris UNSPECIFIED UNSPECIFIED UNSPECIFIED Maarouf, Mohammad UNSPECIFIED UNSPECIFIED UNSPECIFIED Buehrle, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Ullsperger, Markus UNSPECIFIED orcid.org/0000-0003-3970-1982 UNSPECIFIED Sturm, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-488237
DOI:	10.1111/j.1369-1600.2011.00337.x
Journal or Publication Title:	Addict. Biol.
Volume:	16
Number:	4
Page Range:	S. 620 - 624
Date:	2011
Publisher:	WILEY-BLACKWELL
Place of Publication:	MALDEN
ISSN:	1355-6215
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RATS; CONSUMPTION; CORTEX Multiple languages Biochemistry & Molecular Biology; Substance Abuse Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48823