Universität zu Köln

Pfister, R., Barnes, D., Luben, R., Forouhi, N. G., Bochud, M., Khaw, K. -T., Wareham, N. J. and Langenberg, C. (2011). No evidence for a causal link between uric acid and type 2 diabetes: a Mendelian randomisation approach. Diabetologia, 54 (10). S. 2561 - 2570. NEW YORK: SPRINGER. ISSN 1432-0428

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Abstract

Epidemiological and experimental evidence suggests that uric acid has a role in the aetiology of type 2 diabetes. Using a Mendelian randomisation approach, we investigated whether there is evidence for a causal role of serum uric acid for development of type 2 diabetes. We examined the associations of serum-uric-acid-raising alleles of eight common variants recently identified in genome-wide association studies and summarised this in a genetic score with type 2 diabetes in case-control studies including 7,504 diabetes patients and 8,560 non-diabetic controls. We compared the observed effect size to that expected based on: (1) the association between the genetic score and uric acid levels in non-diabetic controls; and (2) the meta-analysed uric acid level to diabetes association. The genetic score showed a linear association with uric acid levels, with a difference of 12.2 mu mol/l (95% CI 9.3, 15.1) by score tertile. No significant associations were observed between the genetic score and potential confounders. No association was observed between the genetic score and type 2 diabetes with an OR of 0.99 (95% CI 0.94, 1.04) per score tertile, significantly different (p = 0.046) from that expected (1.04 [95% CI 1.03, 1.05]) based on the observed uric acid difference by score tertile and the uric acid to diabetes association of 1.21 (95% CI 1.14, 1.29) per 60 mu mol/l. Our results do not support a causal role of serum uric acid for the development of type 2 diabetes and limit the expectation that uric-acid-lowering drugs will be effective in the prevention of type 2 diabetes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pfister, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Barnes, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Luben, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Forouhi, N. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bochud, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Khaw, K. -T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wareham, N. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langenberg, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-488373
DOI:	10.1007/s00125-011-2235-0
Journal or Publication Title:	Diabetologia
Volume:	54
Number:	10
Page Range:	S. 2561 - 2570
Date:	2011
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-0428
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXCESSIVE FRUCTOSE INTAKE; METABOLIC SYNDROME; SERUM URATE; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; GENETIC-LOCI; EPIC-NORFOLK; RISK; GOUT; ASSOCIATION Multiple languages Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48837