Universität zu Köln

Hasan, Alkomiet, McIntosh, Andrew M., Droese, Uta-Aglaia, Schneider-Axmann, Thomas, Lawrie, Stephen M., Moorhead, Thomas William, Tepest, Ralf ORCID: 0000-0002-2421-2652, Maier, Wolfgang, Falkai, Peter ORCID: 0000-0003-2873-8667 and Wobrock, Thomas (2011). Prefrontal cortex gyrification index in twins: an MRI study. Eur. Arch. Psych. Clin. Neurosci., 261 (7). S. 459 - 466. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 0940-1334

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Abstract

Cortical development and folding seems to be under environmental as well as genetic control. The aim of our study was to estimate the genetic influence on gyrification and cortical volumes, comparing prefrontal gyrification index (GI) in monozygotic (MZ) and dizygotic (DZ) twin pairs, and unrelated pairs. Twenty-four subjects (6 pairs of MZ and 6 pairs of DZ twins) were included in this study. Prefrontal cortical folding (gyrification) was measured by an automated and manual version of the gyrification index (A-GI, M-GI) according to previously published protocols. MR-imaging was performed and 3 representative slices were selected from coronar MR-imaging scans. The volumes of the total brain, temporal lobes, prefrontal lobes, and cerebellum were analyzed, too. To evaluate similarity in GI, absolute differences in GI, and brain volumes as well as intraclass correlations of twin pairs were compared with regard to twin status. Finally, a control group of unrelated pairs was assembled from the first two study groups and analyzed. Compared to unrelated pairs, twin pairs exhibited more similarity concerning different brain volumes and a trend to more similarity concerning A-GI. MZ twins did not present more similarity concerning GI (automatically and manually measured) and volume measurements compared to DZ twins. Different factors, like intrauterine factors, postnatal development conditions, and especially environmental factors might account for the differences between related and unrelated pairs. The nonexistence of a pronounced similarity in MZ twins compared to DZ twins concerning prefrontal GI raises questions about the extent of genetic influence on GI.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hasan, Alkomiet UNSPECIFIED UNSPECIFIED UNSPECIFIED McIntosh, Andrew M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Droese, Uta-Aglaia UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider-Axmann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Lawrie, Stephen M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moorhead, Thomas William UNSPECIFIED UNSPECIFIED UNSPECIFIED Tepest, Ralf UNSPECIFIED orcid.org/0000-0002-2421-2652 UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Falkai, Peter UNSPECIFIED orcid.org/0000-0003-2873-8667 UNSPECIFIED Wobrock, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-488386
DOI:	10.1007/s00406-011-0198-2
Journal or Publication Title:	Eur. Arch. Psych. Clin. Neurosci.
Volume:	261
Number:	7
Page Range:	S. 459 - 466
Date:	2011
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	0940-1334
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MONOZYGOTIC TWINS; HUMAN BRAIN; SCHIZOPHRENIA; SPECIFICATION; VARIABILITY; MORPHOLOGY Multiple languages Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48838