Universität zu Köln

Drebber, U., Hardt, A., Dienes, H. -P. and Odenthal, M. (2011). Cytomegalovirus. Pathological-anatomical Manifestation and Verification Procedure. Pathologe, 32 (5). S. 418 - 428. NEW YORK: SPRINGER. ISSN 0172-8113

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Abstract

Human cytomegalovirus, a double-stranded DNA virus, is a member of the Herpesviridae family with high rates of transmission. Primary infection is often asymptomatic and leads to life-long latency. Reactivation may induce different organ manifestations, particularly in the setting of immunosuppression. Histopathologically, the virus can be detected by light microscopy. Different cell populations in different organs are transformed intoowl's eye cells, which are pathognomonic. Immunohistochemistry and electron microscopy can be applied as complementary methods. Various PCR approaches in molecular pathology including nested PCR, capture probe ELISA-PCR and real time PCR confer HCMV tests high sensitivity and specificity. The present article discusses the methods of pathological diagnostic approaches and describes organ manifestations of HCMV.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Drebber, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hardt, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dienes, H. -P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Odenthal, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-489576
DOI:	10.1007/s00292-011-1449-8
Journal or Publication Title:	Pathologe
Volume:	32
Number:	5
Page Range:	S. 418 - 428
Date:	2011
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	0172-8113
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48957