Universität zu Köln

Tueckmantel, Sandra, Greul, Joerg N., Janning, Petra, Brockmeyer, Andreas, Gruetter, Christian, Simard, Jeffrey R., Gutbrod, Oliver, Beck, Michael E., Tietjen, Klaus, Rauh, Daniel ORCID: 0000-0002-1970-7642 and Schreier, Peter H. (2011). Identification of Ustilago maydis Aurora Kinase As a Novel Antifungal Target. ACS Chem. Biol., 6 (9). S. 926 - 934. WASHINGTON: AMER CHEMICAL SOC. ISSN 1554-8937

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Abstract

Infestation of crops by pathogenic fungi has continued to have a major impact by reducing yield and quality, emphasizing the need to identify new targets and. develop new agents to improve methods of crop protection. Here we present Aurora kinase from the phytopathogenic fungus Ustilago maydis as a novel target for N-substituted diaminopyrimidines, a class of small-molecule kinase inhibitors. We,, show that Aurora kinase is essential in U. maydis and that diaminopyrimidines inhibit its activity in vitro. Furthermore, we observed an overall good correlation between in vitro inhibition of Aurora kinase and growth inhibition of diverse fungi in vivo. In vitro inhibition assays with Ustilago and human Aurora kinases indicate that some compounds of the N-substituted diaminopyrimidine class show specificity for the Ustilago enzyme, thus revealing their potential as selective fungicides.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tueckmantel, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Greul, Joerg N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Janning, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Brockmeyer, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruetter, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Simard, Jeffrey R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gutbrod, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Beck, Michael E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tietjen, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Rauh, Daniel UNSPECIFIED orcid.org/0000-0002-1970-7642 UNSPECIFIED Schreier, Peter H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-489643
DOI:	10.1021/cb200112y
Journal or Publication Title:	ACS Chem. Biol.
Volume:	6
Number:	9
Page Range:	S. 926 - 934
Date:	2011
Publisher:	AMER CHEMICAL SOC
Place of Publication:	WASHINGTON
ISSN:	1554-8937
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROTEIN-KINASE; CHROMOSOME SEGREGATION; INHIBITORS; PATHOGENICITY; GENE; SPECIFICITY; ACTIVATION; DISCOVERY; DISEASE; CASCADE Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48964