Universität zu Köln

Moinzadeh, Pia, Krieg, Thomas, Hellmich, Martin ORCID: 0000-0001-5174-928X, Brinckmann, Juergen, Neumann, Elena, Mueller-Ladner, Ulf, Kreuter, Alexander, Dumitrescu, Daniel, Rosenkranz, Stephan and Hunzelmann, Nicolas (2011). Elevated MMP-7 levels in patients with systemic sclerosis: correlation with pulmonary involvement. Exp. Dermatol., 20 (9). S. 770 - 774. MALDEN: WILEY-BLACKWELL. ISSN 0906-6705

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Abstract

Background: Fibrosis is characterized by an excessive accumulation of connective tissue because of an imbalance between synthesis and I degradation of extracellular matrix proteins. Systemic sclerosis (SSc) is a prototypic chronic inflammatory disease leading to a severe fibrosis of the skin and many internal organs. Questions Addressed: We investigated whether serum MMP-7 levels reflect the activity of the fibrotic reaction in systemic sclerosis. Experimental Design: Serum samples were obtained from 123 patients with systemic sclerosis. MMP-serum levels of all patients with SSc were compared with age-matched healthy controls. Results: Significantly increased median serum MMP-7 levels were found in patients with SSc when compared with controls. The median MMP-7 serum level of patients with lung fibrosis (LF) was significantly higher compared with those without LE. Accordingly, patients with dyspnea and DLCO (diffusion capacity of the lung for carbon monoxide) levels below 60% showed significantly higher median MMP-7 levels. Conclusions: Elevated MMP-7 levels are associated with an advanced stage of SSc and LF. These data suggest that in SSc MMP-7 is involved in the process of fibrotic tissue remodelling.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Moinzadeh, Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Krieg, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED orcid.org/0000-0001-5174-928X UNSPECIFIED Brinckmann, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumann, Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller-Ladner, Ulf UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreuter, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Dumitrescu, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenkranz, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hunzelmann, Nicolas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-489725
DOI:	10.1111/j.1600-0625.2011.01321.x
Journal or Publication Title:	Exp. Dermatol.
Volume:	20
Number:	9
Page Range:	S. 770 - 774
Date:	2011
Publisher:	WILEY-BLACKWELL
Place of Publication:	MALDEN
ISSN:	0906-6705
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MATRIX; MATRILYSIN; EXPRESSION; FIBROSIS; GROWTH Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48972