Universität zu Köln

Kreppel, Matthias, Drebber, Uta, Eich, Hans-Theodor, Dreiseidler, Timo, Zoeller, Joachim E., Mueller, Rolf-Peter and Scheer, Martin (2011). Combined-modality treatment in advanced oral squamous cell carcinoma Primary Surgery Followed by Adjuvant Concomitant Radiochemotherapy. Strahlenther. Onkol., 187 (9). S. 555 - 561. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-099X

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Abstract

Background: The efficacy of adjuvant radiochemotherapy (RCT) in patients with advanced stage head and neck carcinoma has been proven in prospective randomized trials. However, these trials focused on different head and neck sites. Specific analyses for treatment effects in squamous cell carcinoma of the oral cavity (OSCC) are missing. We evaluated our experiences with adjuvant concomitant RCT in advanced OSCC to compare the results with other treatment schemes using adjuvant RCT. Patients and Methods:A total of 183 patients with OSCC of UICC stages II-IVb were reviewed retrospectively. All patients were treated with radical surgery followed by adjuvant, conventional fractionated concomitant RCT using carboplatin. Overall survival was plotted by Kaplan-Meier analysis. Prognostic factors were identified through univariate and multivariate analysis. Results:Univariate analysis showed a significant impact of T, N, and UICC stage, histopathologic grading, surgical margins, extracaspular spread (ECS), and lymphangiosis carcinomatosa on overall survival (Table 3). Patients with stage IVa had a higher 5-year overall survival rate (42.8%) than patients with stage IVb (25.0%) (Figure 1). The differences were significant in multivariate analysis (p = 0.033) (Table 4). Conclusion:Adjuvant concomitant RCT is an effective treatment in patients with advanced stage OSCC. However, it remains unclear, which patients should be treated with adjuvant RCT. For patients with stage IVb, adjuvant RCT yields poor results. Prospective randomized trials are needed to confirm which patients should be treated with adjuvant RCT.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Drebber, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED Eich, Hans-Theodor UNSPECIFIED UNSPECIFIED UNSPECIFIED Dreiseidler, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, Joachim E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Rolf-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-489862
DOI:	10.1007/s00066-010-2245-8
Journal or Publication Title:	Strahlenther. Onkol.
Volume:	187
Number:	9
Page Range:	S. 555 - 561
Date:	2011
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1439-099X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOCALLY ADVANCED HEAD; LONG-TERM SURVIVAL; NECK-CANCER; CONCURRENT CHEMORADIOTHERAPY; RADIATION-THERAPY; PREOPERATIVE RADIOCHEMOTHERAPY; POSTOPERATIVE IRRADIATION; RANDOMIZED-TRIAL; CHEMOTHERAPY; RADIOTHERAPY Multiple languages Oncology; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48986