Universität zu Köln

Floeth, Frank W., Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Herdmann, Joerg, Eicker, Sven, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Steiger, Hans-Jakob ORCID: 0000-0002-8249-2998 and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2011). RETRACTED: Prognostic Value of F-18-FDG PET in Monosegmental Stenosis and Myelopathy of the Cervical Spinal Cord (Retracted article. See vol. 52, pg. 1663, 2011). J. Nucl. Med., 52 (9). S. 1385 - 1392. RESTON: SOC NUCLEAR MEDICINE INC. ISSN 0161-5505

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Abstract

MRI offers perfect visualization of spondylotic stenosis of the cervical spine, but morphologic imaging does not correlate with clinical symptoms and postoperative recovery after decompression surgery. In this prospective study, we investigated the role of F-18-FDG PET in patients with degenerative stenosis of the cervical spinal cord in relation to postsurgical outcome. Methods: Twenty patients with monosegmental spondylotic stenosis of the middle cervical spine (C3/C4 or C4/C5) showing intramedullary hyperintensity on T2-weighted MRI and clinical symptoms of myelopathy (myelopathic patients) were investigated by F-18-FDG PET. Maximum standardized uptake values (SUVmax) were measured at all levels of the cervical spine (C1-C7). Decompression surgery and anterior cervical fusion were performed on all patients, and clinical status (Japanese Orthopedic Association [JOA] score) was assessed before and 6 mo after surgery. The F-18-FDG data of 10 individuals without cervical spine pathology were used as a reference (controls). Results: The myelopathic patients showed a significant decrease in F-18-FDG uptake in the area of the lower cervical cord, compared with the control group (C7 SUVmax, 1.49 +/- 0.18 vs. 1.71 +/- 0.27, P = 0.01). Ten myelopathic patients exhibited focally increased F-18-FDG uptake at the level of the stenosis (SUVmax, 2.27 +/- 0.41 vs. 1.75 +/- 0.22, P = 0.002). The remaining 10 patients showed inconspicuous F-18-FDG uptake at the area of the stenosis. Postoperatively, the patients with focally increased F-18-FDG accumulation at the level of stenosis showed good clinical recovery and a significant improvement in JOA scores (13.6 +/- 2.3 vs. 9.5 +/- 2.5, P = 0.001), whereas no significant improvement was observed in the remaining patients (JOA score, 12.0 +/- 2.4 vs. 11.6 +/- 2.5, not statistically significant). Multiple regression analysis identified the presence of focally increased F-18-FDG uptake at the level of the stenosis as an independent predictor of postoperative outcome (P = 0.002). Conclusion: The results suggest that regional changes in F-18-FDG uptake have prognostic significance in compression-induced cervical myelopathy that may be helpful in decisions on the timing of surgery.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Floeth, Frank W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Herdmann, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Eicker, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Steiger, Hans-Jakob UNSPECIFIED orcid.org/0000-0002-8249-2998 UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-489996
DOI:	10.2967/jnumed.111.091801
Journal or Publication Title:	J. Nucl. Med.
Volume:	52
Number:	9
Page Range:	S. 1385 - 1392
Date:	2011
Publisher:	SOC NUCLEAR MEDICINE INC
Place of Publication:	RESTON
ISSN:	0161-5505
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; SPONDYLOTIC MYELOPATHY; COMPRESSIVE MYELOPATHY; SIGNAL INTENSITY; LUNG-CANCER; FDG; RESOLUTION; MOUSE; IRRADIATION; METASTASES Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48999