Universität zu Köln

Joussen, Antonia M., Rizzo, Stanislao, Kirchhof, Bernd, Schrage, Norbert, Li, Xiaoxin, Lente, Christina and Hilgers, Ralf-Dieter ORCID: 0000-0002-5945-1119 (2011). Heavy silicone oil versus standard silicone oil in as vitreous tamponade in inferior PVR (HSO Study): interim analysis. Acta Ophthalmol., 89 (6). S. E483 - 7. HOBOKEN: WILEY-BLACKWELL. ISSN 1755-375X

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Abstract

Purpose: The Heavy Silicone Oil versus Standard Silicone Oil Study (HSO study) is designed to answer the question whether a heavier-than-water tamponade improves the prognosis of eyes with proliferative vitreoretinopathy (PVR) of the lower retina. Methods: The HSO Study is a multicentre, randomized, prospective, controlled clinical trial stratified by surgeon comparing two endotamponades within a two-arm parallel-group design. Patients with inferiorly and posteriorly located PVR grade C-A6 were randomized to either HSO or standard silicone oil as a tamponading agent. The main end-point criteria are complete retinal attachment at 12 months and change in visual acuity (VA) 12 months post-operatively compared to the preoperative VA. Results: Forty-six patients treated with HSO were compared to 47 patients treated with standard silicone oil. There was no difference among the groups regarding baseline data. Three patients in the HSO and five patients in the standard silicone oil group fulfilled intraoperative exclusion criteria. There was no significant difference between both groups regarding anatomical success. Neither noninferiority nor superiority was shown with regard to final acuity. Conclusions: The HSO Study is the first randomized prospective clinical trial to compare heavy and standard silicone oil in patients with PVR of the lower retina. The intermediate results failed to demonstrate superiority of a heavy tamponade.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Joussen, Antonia M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rizzo, Stanislao UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchhof, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Schrage, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Xiaoxin UNSPECIFIED UNSPECIFIED UNSPECIFIED Lente, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hilgers, Ralf-Dieter UNSPECIFIED orcid.org/0000-0002-5945-1119 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-490101
DOI:	10.1111/j.1755-3768.2011.02139.x
Journal or Publication Title:	Acta Ophthalmol.
Volume:	89
Number:	6
Page Range:	S. E483 - 7
Date:	2011
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1755-375X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RETINAL-DETACHMENT Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49010