Universität zu Köln

von Tresckow, Bastian and Engert, Andreas (2011). The Role of Autologous Transplantation in Hodgkin Lymphoma. Curr. Hematol. Malig. Rep., 6 (3). S. 172 - 180. PHILADELPHIA: CURRENT MEDICINE GROUP. ISSN 1558-822X

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Abstract

Between 80% and 90% of Hodgkin lymphoma (HL) patients can be cured with up-to-date combined-modality treatments, but patients with disease refractory to first-line therapy and those who relapse after first-line therapy still have a relatively poor prognosis. Dose intensification with stem cell support has been evaluated both to avoid relapses and to cure patients with refractory or relapsed disease. In this review, we focus on the use of high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) in first-line, second-line, and third-line therapy for HL patients. The relevance of salvage therapy before high-dose chemotherapy is discussed, as well as the role of sequential high dose chemotherapy. We also review current evidence for tandem transplantation in high-risk HL patients and ASCT in elderly patients. Finally, we discuss current concepts of ASCT for HL patients and the use of functional imaging and consolidation therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code von Tresckow, Bastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Engert, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-490230
DOI:	10.1007/s11899-011-0091-0
Journal or Publication Title:	Curr. Hematol. Malig. Rep.
Volume:	6
Number:	3
Page Range:	S. 172 - 180
Date:	2011
Publisher:	CURRENT MEDICINE GROUP
Place of Publication:	PHILADELPHIA
ISSN:	1558-822X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; HIGH-DOSE THERAPY; POSITRON-EMISSION-TOMOGRAPHY; SALVAGE CHEMOTHERAPY; FDG-PET; SEQUENTIAL CHEMOTHERAPY; CONVENTIONAL THERAPY; PREDICTIVE-VALUE; ACTIVE REGIMEN Multiple languages Oncology; Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49023