Universität zu Köln

Shmygalev, Sergey, Damm, Martin, Weckbecker, Klaus, Berghaus, Guenter, Petzke, Frank and Sabatowski, Rainer ORCID: 0000-0003-2228-3147 (2011). The impact of long-term maintenance treatment with buprenorphine on complex psychomotor and cognitive function. Drug Alcohol Depend., 117 (2-3). S. 190 - 198. CLARE: ELSEVIER IRELAND LTD. ISSN 1879-0046

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Abstract

Introduction: Despite the fact that buprenorphine is effective, well tolerated and due to its pharmacological profile a very safe drug, the impact of long-term buprenorphine substitution therapy on complex psychomotor and cognitive function predicting driving ability is not yet clear. Therefore, a prospective comparison between patients receiving sublingual buprenorphine and a control group of untreated, healthy volunteers was performed. Methods: Treated and untreated subjects were matched for age and sex, with three control subjects selected for every buprenorphine patient. Patients using unreported drugs were included in the intention-to-treat (HT) analysis; the remaining patients were analysed as the per-protocol (PP) group. The test battery comprised the assessment of: performance during stress, visual orientation, concentration, attention, vigilance and reaction time. The primary endpoint was defined as the sum of the relevant scores of the tests after z-transformation of the individual scores. Results: 30 patients with sublingual buprenorphine treatment (7.7 +/- 3.9 mg per day) were matched to 90 controls. 19 patients were excluded from the PP-analysis because of additional unreported drug intake. Significant non-inferiority could be demonstrated for the PP-group (p < 0.05) as well as for the HT-group (p < 0.001). Conclusion: Patients receiving a stable dose of sublingual buprenorphine showed no significant impairment of complex psychomotor or cognitive performance as compared to healthy controls. However intake of illicit drugs as well as the lack of social reliability are major problems in this specific patients group. Despite of the absence of a relevant impact of the drug on driving ability, those patients do not seem to be qualified for getting their driving license. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Shmygalev, Sergey UNSPECIFIED UNSPECIFIED UNSPECIFIED Damm, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Weckbecker, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Berghaus, Guenter UNSPECIFIED UNSPECIFIED UNSPECIFIED Petzke, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabatowski, Rainer UNSPECIFIED orcid.org/0000-0003-2228-3147 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-490267
DOI:	10.1016/j.drugalcdep.2011.01.017
Journal or Publication Title:	Drug Alcohol Depend.
Volume:	117
Number:	2-3
Page Range:	S. 190 - 198
Date:	2011
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1879-0046
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language METHADONE-MAINTAINED PATIENTS; NONCANCER PAIN PATIENTS; DRIVING ABILITY; HEALTHY-VOLUNTEERS; OPIOID DEPENDENCE; PERFORMANCE; IMPAIRMENT; MORPHINE; THERAPY; ALCOHOL Multiple languages Substance Abuse; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49026