Universität zu Köln

Schlaak, M., Schwind, S., Wetzig, T., Maschke, J., Treudler, R., Basara, N., Lange, T., Simon, J. C., Niederwieser, D. and Al-Ali, H. K. (2010). UVA (UVA-1) therapy for the treatment of acute GVHD of the skin. Bone Marrow Transplant., 45 (12). S. 1741 - 1749. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5365

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Abstract

Long-wavelength UVA (340-400 nm UVA-1) phototherapy has been reported to be effective in atopic dermatitis, localized scleroderma and T-cell-derived skin diseases. We retrospectively investigated 70 patients with acute cutaneous GVHD after allogeneic haematopoietic cell transplantation or donor lymphocyte infusion. Complete and partial responses with a median duration of 10 months were achieved in 49 (70%) and 17 (24.3%) patients, respectively. Overall, 47 (67.1%) patients were not treated with systemic steroids. Furthermore, immunosuppression could be tapered in 24 (34.3%) patients while they were receiving UVA-1 treatment. Responses were seen irrespective of age or type of conditioning. Treatment was very well tolerated. After a median follow-up of 18 (range 10-60) months, three patients developed epithelial skin neoplasia. We conclude that UVA-1 therapy is feasible, well tolerated and can be an effective treatment for acute GVHD of the skin, thereby avoiding the use of systemic steroids and/or allowing a more rapid tapering of systemic immunosuppression in a substantial number of patients. The results of this retrospective analysis warrant larger, prospective studies and the effectiveness of UVA-1 therapy should be compared with other established treatment modalities. Bone Marrow Transplantation (2010) 45, 1741-1748; doi:10.1038/bmt.2010.230; published online 4 October 2010

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schlaak, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwind, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wetzig, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maschke, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Treudler, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Basara, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lange, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, J. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Niederwieser, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Al-Ali, H. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-491156
DOI:	10.1038/bmt.2010.230
Journal or Publication Title:	Bone Marrow Transplant.
Volume:	45
Number:	12
Page Range:	S. 1741 - 1749
Date:	2010
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-5365
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; ACUTE GRAFT; ULTRAVIOLET; PHOTOTHERAPY; RADIATION; RECIPIENTS; PUVA; PROPHYLAXIS Multiple languages Biophysics; Oncology; Hematology; Immunology; Transplantation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49115