Universität zu Köln

Grimal, Sophie, Puech, Sylvie, Wagener, Raimund, Venteo, Stephanie, Carroll, Patrick ORCID: 0000-0003-3287-8195 and Fichard-Carroll, Agnes (2010). Collagen XXVIII Is a Distinctive Component of the Peripheral Nervous System Nodes of Ranvier and Surrounds Nonmyelinating Glial Cells. Glia, 58 (16). S. 1977 - 1988. HOBOKEN: WILEY. ISSN 1098-1136

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Abstract

Growing evidence indicates that collagens perform crucial functions during the development and organization of the nervous system. Collagen XXVIII is a recently discovered collagen almost exclusively expressed in the peripheral nervous system (PNS). In this study, we show that this collagen is associated with nonmyelinated regions of the PNS. With the notable exception of type II terminal Schwann cell in the hairy skin, collagen XXVIII surrounds all nonmyelinating glial cells studied. This includes satellite glial cells of the dorsal root ganglia, terminal Schwann cells type I around mechanoceptors in the skin, terminal Schwann cells around proprioceptors in the muscle spindle or at the neuromuscular junction and olfactory ensheathing cells. Collagen XXVIII is also detected at nodes of Ranvier where the myelin sheath of myelinated fibers is interrupted and is thus a distinctive component of the PNS nodal gap. The correlation between the absence of myelin and the presence of collagen XXVIII is confirmed in a mouse model of Charcot-Marie-Tooth characterized by dysmyelinated nerve fibers, in which enhancement of collagen XXVIII labeling is observed. (C) 2010 Wiley-Liss, Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grimal, Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Puech, Sylvie UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagener, Raimund UNSPECIFIED UNSPECIFIED UNSPECIFIED Venteo, Stephanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Carroll, Patrick UNSPECIFIED orcid.org/0000-0003-3287-8195 UNSPECIFIED Fichard-Carroll, Agnes UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-491447
DOI:	10.1002/glia.21066
Journal or Publication Title:	Glia
Volume:	58
Number:	16
Page Range:	S. 1977 - 1988
Date:	2010
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1098-1136
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXTRACELLULAR-MATRIX; MYELINATED AXONS; SCHWANN-CELLS; BASAL LAMINA; EXPRESSION; INJURY; DIFFERENTIATION; REGENERATION; MAINTENANCE; GLIOMEDIN Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49144