Universität zu Köln

Schennach-Wolff, Rebecca, Obermeier, Michael, Seemueller, Florian, Jaeger, Markus, Schmauss, Max, Laux, Gerd, Pfeiffer, Herbert, Naber, Dieter, Schmidt, Lutz G., Gaebel, Wolfgang, Klosterkoetter, Joachim, Heuser, Isabella, Maier, Wolfgang, Lemke, Matthias R., Ruether, Eckart, Klingberg, Stefan ORCID: 0000-0001-8081-7181, Gastpar, Markus, Engel, Rolf R., Moeller, Hans-Juergen and Riedel, Michael (2010). Does Clinical Judgment of Baseline Severity and Changes in Psychopathology Depend on the Patient Population? Results of a CGI and PANSS Linking Analysis in a Naturalistic Study. J. Clin. Psychopharmacol., 30 (6). S. 726 - 732. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 0271-0749

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Abstract

Background: Linking of the Clinical Global Impression (CGI) Scale and the Positive and Negative Syndrome Scale (PANSS) was performed within a naturalistic sample. Furthermore, these linking results were compared with those derived from randomized controlled trials to examine if the baseline severity might influence the linking results. Methods: Biweekly PANSS and CGI ratings were performed from admission to discharge in 398 schizophrenia patients treated within a naturalistic study. Equipercentile linking was performed using the statistical program, R 2.8.1. To evaluate how the naturalistic study design would influence linkage results, a so-called study sample was computed with patients of the naturalistic study fulfilling common inclusion criteria of randomized controlled trials (n = 199). Patients not fulfilling these criteria (less ill sample) and those fulfilling the criteria (study sample) were compared using confidence intervals. Results: We found a considerable difference between the linking of the CGI severity score and the PANSS total score comparing the less ill sample and the study sample. Being considered mildly ill'' at admission in the less ill sample corresponded to a PANSS total score of 47 points and to a PANSS total score of 67 points in the study sample. Considering the linking of the CGI improvement score and PANSS changes, similar results were found for CGI improvement ratings ranging from very much improved'' to minimally improved.'' Conclusions: Despite considerable differences, a 50% PANSS reduction was found to correspond to a clinical rating of much improved, which seems to be a suitable definition for response in clinical drug trials.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schennach-Wolff, Rebecca UNSPECIFIED UNSPECIFIED UNSPECIFIED Obermeier, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Seemueller, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Jaeger, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmauss, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Laux, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfeiffer, Herbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Naber, Dieter UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Lutz G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaebel, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Heuser, Isabella UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemke, Matthias R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruether, Eckart UNSPECIFIED UNSPECIFIED UNSPECIFIED Klingberg, Stefan UNSPECIFIED orcid.org/0000-0001-8081-7181 UNSPECIFIED Gastpar, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Engel, Rolf R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moeller, Hans-Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-491664
DOI:	10.1097/JCP.0b013e3181faf39b
Journal or Publication Title:	J. Clin. Psychopharmacol.
Volume:	30
Number:	6
Page Range:	S. 726 - 732
Date:	2010
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	0271-0749
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DOUBLE-BLIND; SCHIZOPHRENIA; OLANZAPINE Multiple languages Pharmacology & Pharmacy; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49166