Enciso-Mora, Victor, Broderick, Peter ORCID: 0000-0002-8348-5829, Ma, Yussanne, Jarrett, Ruth F., Hjalgrim, Henrik, Hemminki, Kari, van den Berg, Anke ORCID: 0000-0002-8894-2638, Olver, Bianca, Lloyd, Amy, Dobbins, Sara E., Lightfoot, Tracy, van Leeuwen, Flora E., Foersti, Asta, Diepstra, Arjan ORCID: 0000-0001-9239-1050, Broeks, Annegien, Vijayakrishnan, Jayaram ORCID: 0000-0002-8284-2249, Shield, Lesley, Lake, Annette, Montgomery, Dorothy, Roman, Eve, Engert, Andreas, von Strandmann, Elke Pogge, Reiners, Katrin S., Nolte, Ilja M., Smedby, Karin E., Adami, Hans-Olov, Russell, Nicola S., Glimelius, Bengt, Hamilton-Dutoit, Stephen ORCID: 0000-0003-2158-3885, de Bruin, Marieke, Ryder, Lars P., Molin, Daniel, Sorensen, Karina Meden, Chang, Ellen T., Taylor, Malcolm, Cooke, Rosie, Hofstra, Robert ORCID: 0000-0001-7498-3829, Westers, Helga, van Wezel, Tom ORCID: 0000-0001-5773-7730, van Eijk, Ronald ORCID: 0000-0001-7955-6295, Ashworth, Alan, Rostgaard, Klaus ORCID: 0000-0001-6220-9414, Melbye, Mads, Swerdlow, Anthony J. and Houlston, Richard S. (2010). A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). Nature Genet., 42 (12). S. 1126 - 1132. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1546-1718

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Abstract

To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 x 10(-8)), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 x 10(-13)) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 x 10(-8)). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 x 10(-50)). These data provide new insight into the pathogenesis of cHL.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Enciso-Mora, VictorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broderick, PeterUNSPECIFIEDorcid.org/0000-0002-8348-5829UNSPECIFIED
Ma, YussanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jarrett, Ruth F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hjalgrim, HenrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hemminki, KariUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van den Berg, AnkeUNSPECIFIEDorcid.org/0000-0002-8894-2638UNSPECIFIED
Olver, BiancaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lloyd, AmyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dobbins, Sara E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lightfoot, TracyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Leeuwen, Flora E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foersti, AstaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diepstra, ArjanUNSPECIFIEDorcid.org/0000-0001-9239-1050UNSPECIFIED
Broeks, AnnegienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vijayakrishnan, JayaramUNSPECIFIEDorcid.org/0000-0002-8284-2249UNSPECIFIED
Shield, LesleyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lake, AnnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montgomery, DorothyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roman, EveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engert, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Strandmann, Elke PoggeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reiners, Katrin S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nolte, Ilja M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smedby, Karin E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adami, Hans-OlovUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Russell, Nicola S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glimelius, BengtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamilton-Dutoit, StephenUNSPECIFIEDorcid.org/0000-0003-2158-3885UNSPECIFIED
de Bruin, MariekeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ryder, Lars P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Molin, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sorensen, Karina MedenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chang, Ellen T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taylor, MalcolmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cooke, RosieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hofstra, RobertUNSPECIFIEDorcid.org/0000-0001-7498-3829UNSPECIFIED
Westers, HelgaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Wezel, TomUNSPECIFIEDorcid.org/0000-0001-5773-7730UNSPECIFIED
van Eijk, RonaldUNSPECIFIEDorcid.org/0000-0001-7955-6295UNSPECIFIED
Ashworth, AlanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rostgaard, KlausUNSPECIFIEDorcid.org/0000-0001-6220-9414UNSPECIFIED
Melbye, MadsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Swerdlow, Anthony J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Houlston, Richard S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-491948
DOI: 10.1038/ng.696
Journal or Publication Title: Nature Genet.
Volume: 42
Number: 12
Page Range: S. 1126 - 1132
Date: 2010
Publisher: NATURE PUBLISHING GROUP
Place of Publication: NEW YORK
ISSN: 1546-1718
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
KAPPA-B-ALPHA; INFECTIOUS-MONONUCLEOSIS; COLORECTAL-CANCER; NEOPLASTIC-CELLS; PROSTATE-CANCER; INCREASED RISK; C-MYC; DISEASE; GENE; VARIANTMultiple languages
Genetics & HeredityMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/49194

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