Universität zu Köln

Kremer, Malte C., Christiansen, Frauke, Leiss, Florian, Paehler, Moritz, Knapek, Stephan, Andlauer, Till F. M., Foerstner, Friedrich, Kloppenburg, Peter, Sigrist, Stephan J. and Tavosanis, Gaia ORCID: 0000-0002-8679-5515 (2010). Structural Long-Term Changes at Mushroom Body Input Synapses. Curr. Biol., 20 (21). S. 1938 - 1945. CAMBRIDGE: CELL PRESS. ISSN 1879-0445

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Abstract

How does the sensory environment shape circuit organization in higher brain centers? Here we have addressed the dependence on activity of a defined circuit within the mushroom body of adult Drosophila. This is a brain region receiving olfactory information and involved in long-term associative memory formation [1]. The main mushroom body input region, named the calyx, undergoes volumetric changes correlated with alterations of experience [2-5]. However, the underlying modifications at the cellular level remained unclear. Within the calyx, the clawed dendritic endings of mushroom body Kenyon cells form microglomeruli, distinct synaptic complexes with the presynaptic boutons of olfactory projection neurons [6, 7]. We developed tools for high-resolution imaging of pre- and postsynaptic compartments of defined calycal microglomeruli. Here we show that preventing firing of action potentials or synaptic transmission in a small, identified fraction of projection neurons causes alterations in the size, number, and active zone density of the microglomeruli formed by these neurons. These data provide clear evidence for activity-dependent organization of a circuit within the adult brain of the fly.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kremer, Malte C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Christiansen, Frauke UNSPECIFIED UNSPECIFIED UNSPECIFIED Leiss, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Paehler, Moritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Knapek, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Andlauer, Till F. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Foerstner, Friedrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Kloppenburg, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Sigrist, Stephan J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tavosanis, Gaia UNSPECIFIED orcid.org/0000-0002-8679-5515 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-492602
DOI:	10.1016/j.cub.2010.09.060
Journal or Publication Title:	Curr. Biol.
Volume:	20
Number:	21
Page Range:	S. 1938 - 1945
Date:	2010
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1879-0445
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HONEYBEE APIS-MELLIFERA; DROSOPHILA-MELANOGASTER; SYNAPTIC ORGANIZATION; SENSORY EXPERIENCE; OLFACTORY CIRCUIT; NERVOUS-SYSTEM; NEURONS; MEMORY; PLASTICITY; BODIES Multiple languages Biochemistry & Molecular Biology; Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49260