Universität zu Köln

Mareck, Ute, Geyer, Hans, Fusshoeller, Gregor, Schwenke, Anne, Haenelt, Nadine, Piper, Thomas ORCID: 0000-0002-7462-6693, Thevis, Mario and Schaenzer, Wilhelm (2010). Reporting and managing elevated testosterone/epitestosterone ratios - Novel aspects after five years' experience. Drug Test. Anal., 2 (11-12). S. 637 - 643. MALDEN: WILEY-BLACKWELL. ISSN 1942-7603

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Abstract

The testosterone/epitestosterone (T/E) ratio was implemented as an indirect parameter for the detection of testosterone administration with an empirically established threshold value at T/E = 6. In 2005, the T/E reporting threshold was lowered from six to four. Between 2005 and 2009, 63 510 doping control urine samples were analyzed in the Cologne laboratory. A total of 1442 specimens (2.3%) showed a T/E > 4;80 (5.5%) of which were tested positive by means of isotope ratio mass spectrometry (IRMS); and most of which (68) originated from strength sport disciplines. Specimens of high T/E ratio showed a much higher probability for being confirmed to contain exogenous testosterone using IRMS analysis than samples of low T/E values. Considering the small number of adverse analytical findings triggered by lowering the T/E reporting threshold (978 urine specimens with T/E ratios between 4 and 6 yielded only 4 (0.4%) positive IRMS findings) and the known limitations of the T/E ratio as discriminating parameter (UGT2B17 polymorphism), the currently mandatory approach shows only marginal overall efficiency. A more effective tool for the detection of the misuse of testosterone would be the implementation of individual reference ranges. Until athlete steroidal passports are available, it is suggested to exceed the threshold level for T/E from 4 to 6 and perform obligatory IRMS analysis for specimens showing T/E > 6. Further conditions triggering IRMS analysis could be suppressed luteinizing hormone (LH) values in males and disproportionate changes of relevant parameters in individual profiles evidently not resulting from ethanol consumption. Copyright (C) 2010 John Wiley & Sons, Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mareck, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED Geyer, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Fusshoeller, Gregor UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwenke, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Haenelt, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Piper, Thomas UNSPECIFIED orcid.org/0000-0002-7462-6693 UNSPECIFIED Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaenzer, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-493182
DOI:	10.1002/dta.234
Journal or Publication Title:	Drug Test. Anal.
Volume:	2
Number:	11-12
Page Range:	S. 637 - 643
Date:	2010
Publisher:	WILEY-BLACKWELL
Place of Publication:	MALDEN
ISSN:	1942-7603
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOGENOUS URINARY STEROIDS; DOPING CONTROL PURPOSES; TESTOSTERONE ABUSE; C-13/C-12 RATIOS; T/E RATIO; EPITESTOSTERONE; POLYMORPHISM; POPULATION Multiple languages Biochemical Research Methods; Chemistry, Analytical; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49318