Universität zu Köln

Schmitt, Manfred, Mengele, Karin, Napieralski, Rudolf, Magdolen, Viktor, Reuning, Ute, Gkazepis, Apostolos, Sweep, Fred ORCID: 0000-0003-1103-3070, Brunner, Nils, Foekens, John and Harbeck, Nadia (2010). Clinical utility of level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1. Expert Rev. Mol. Diagn., 10 (8). S. 1051 - 1068. OSLO: TAYLOR & FRANCIS AS. ISSN 1744-8352

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Abstract

The prognostic and/or predictive value of the cancer biomarkers, urokinase-type plasminogen activator (uPA) and its inhibitor (plasminogen activator inhibitor [PAI]-1), determined by ELISA in tumor-tissue extracts, was demonstrated for several cancer types in numerous clinically relevant retrospective or prospective studies, including a multicenter breast cancer therapy trial (Chemo-NO). Consequently, for the first time ever for any cancer biomarker for breast cancer, uPA and PAI-1 have reached the highest level of evidence, level-of-evidence-1. At present, two other breast cancer therapy trials, NNBC-3 and Plan B, also incorporating uPA and PAI-1 as treatment-assignment tools are in effect. Furthermore, small synthetic molecules targeting uPA are currently in Phase II clinical trials in patients afflicted with advanced cancer of the ovary, breast or pancreas.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schmitt, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED Mengele, Karin UNSPECIFIED UNSPECIFIED UNSPECIFIED Napieralski, Rudolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Magdolen, Viktor UNSPECIFIED UNSPECIFIED UNSPECIFIED Reuning, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED Gkazepis, Apostolos UNSPECIFIED UNSPECIFIED UNSPECIFIED Sweep, Fred UNSPECIFIED orcid.org/0000-0003-1103-3070 UNSPECIFIED Brunner, Nils UNSPECIFIED UNSPECIFIED UNSPECIFIED Foekens, John UNSPECIFIED UNSPECIFIED UNSPECIFIED Harbeck, Nadia UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-493287
DOI:	10.1586/ERM.10.71
Journal or Publication Title:	Expert Rev. Mol. Diagn.
Volume:	10
Number:	8
Page Range:	S. 1051 - 1068
Date:	2010
Publisher:	TAYLOR & FRANCIS AS
Place of Publication:	OSLO
ISSN:	1744-8352
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PLASMINOGEN-ACTIVATOR INHIBITOR-1; SQUAMOUS-CELL CARCINOMA; UROKINASE-TYPE; BREAST-CANCER; PROGNOSTIC IMPACT; LUNG-CANCER; GENE-EXPRESSION; RENAL-CELL; PROSTATE-CANCER; HIGH-RISK Multiple languages Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49328