Universität zu Köln

Gehrmann, Ulrich, Kuss, Oliver ORCID: 0000-0003-3301-5869, Wellmann, Juergen and Bender, Ralf (2010). Logistic regression was preferred to estimate risk differences and numbers needed to be exposed adjusted for covariates. J. Clin. Epidemiol., 63 (11). S. 1223 - 1232. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1878-5921

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Abstract

Objective: The estimation of the number needed to be exposed (NNE) with adjustment for covariates can be performed by inverting the corresponding adjusted risk difference. The latter can be estimated by several approaches based on binomial and Poisson regression with or without constraints. A novel proposal is given by logistic regression with average risk difference (LR-ARD) estimation. Finally, the use of ordinary linear regression and unadjusted estimation can be considered. Study Design and Setting: LR-ARD is compared with alternative approaches regarding bias, precision, and coverage probability by means of an extensive simulation study. Results: LR-ARD was found to be superior compared with the other approaches. In the case of balanced covariates and large sample sizes, unadjusted estimation and ordinary linear regression can also be used. In general, however, LR-ARD seems to be the most appropriate approach to estimate adjusted risk differences and NNEs. Conclusions: To estimate risk differences and NNEs with adjustment for covariates, the LR-ARD approach should be used. (C) 2010 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gehrmann, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuss, Oliver UNSPECIFIED orcid.org/0000-0003-3301-5869 UNSPECIFIED Wellmann, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Bender, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-493520
DOI:	10.1016/j.jclinepi.2010.01.011
Journal or Publication Title:	J. Clin. Epidemiol.
Volume:	63
Number:	11
Page Range:	S. 1223 - 1232
Date:	2010
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1878-5921
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CONFIDENCE-INTERVALS; VARIABLES; RATIOS; TREAT Multiple languages Health Care Sciences & Services; Public, Environmental & Occupational Health Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49352