Universität zu Köln

Lazova, Rossitza, Tantcheva-Poor, Iliana and Sigal, Alicia C. (2010). P75 nerve growth factor receptor staining is superior to S100 in identifying spindle cell and desmoplastic melanoma. J. Am. Acad. Dermatol., 63 (5). S. 852 - 859. NEW YORK: MOSBY-ELSEVIER. ISSN 0190-9622

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Abstract

Background: Spindle cell melanoma (SCM) including desmoplastic melanoma (DM) is a rare variant of malignant melanoma that may present diagnostic difficulties particularly when staining with S100 is negative, weak, focal, or a combination of these. Conventional melanocytic markers in SCM are usually negative. Objective: We sought to compare the staining of p75 nerve growth factor receptor (NGF-R) and S100 in SCMs. Methods: We evaluated the staining of p75 NGF-R and S100 in 13 cases of SCMs: 3 SCMs without desmoplasia, 5 pure DMs, and 5 combined DMs with a conventional component. Results: Staining with p75 NGF-R was positive in 13 of 13 (100%) cases of SCMs. In 3 cases the intensity of staining and the percentage of cells staining with this marker were greater than those with S100. One case of SCM was negative for S100 but demonstrated strong expression of p75 NGF-R. One case was focally and weakly positive with S100 but expressed strong positive staining with p75 NGF-R. Absence of staining with p75 NGF-R was noted in the conventional round cell component of two of 5 (40%) combined DMs whereas the same areas were strongly positive for human melanoma black (HMB)-45 and Melan-A. In 5 of 5 (100%) cases of combined DMs the desmoplastic component stained positive with p75 NGF-R, demonstrating an inverse relationship with the staining of conventional melanocytic markers. Limitations: Small study size was a limitation. Conclusion: p75 NGF-R exhibits superior staining characteristics and greater sensitivity in identifying SCM and DMs than S100. P75 NGF-R may be a useful diagnostic and ancillary stain in addition to S100. (J Am Acad Dermatol 2010;63:852-8.)

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lazova, Rossitza UNSPECIFIED UNSPECIFIED UNSPECIFIED Tantcheva-Poor, Iliana UNSPECIFIED UNSPECIFIED UNSPECIFIED Sigal, Alicia C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-493678
DOI:	10.1016/j.jaad.2009.11.688
Journal or Publication Title:	J. Am. Acad. Dermatol.
Volume:	63
Number:	5
Page Range:	S. 852 - 859
Date:	2010
Publisher:	MOSBY-ELSEVIER
Place of Publication:	NEW YORK
ISSN:	0190-9622
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MALIGNANT-MELANOMA; NEUROTROPIC MELANOMA; CLINICOPATHOLOGICAL ANALYSIS; DIAGNOSTIC PITFALL; S-100 PROTEIN; SCHWANN-CELL; NEURAL CREST; DIFFERENTIATION; EXPRESSION; VARIANT Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49367