Universität zu Köln

Wolff, R. Schennach, Moller, H. J., Jager, M., Seemuller, F., Obermeier, M., Messer, T., Laux, G., Pfeiffer, H., Naber, D., Schmidt, L. G., Gaebel, W., Klosterkotter, J., Heuser, I., Maier, W., Lemke, M. R., Ruther, E., Klingberg, S., Gastpar, M. and Riedel, M. (2010). A Critical Analysis and Discussion of the Appropriateness of the Schizophrenia Consensus Remission Criteria in Clinical Pharmaceutical Trials. Pharmacopsychiatry, 43 (7). S. 245 - 252. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-0795

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Abstract

Background The aim of this paper is to apply the proposed consensus remission criteria to an acutely ill inpatient sample at admission and evaluate their adaptability in this patient population and pharmaceutical trials Methods The Remission in Schizophrenia Working Group s consensus criteria were applied to 272 acutely ill schizophrenia patients Patients were examined using the PANSS HAMD UKU and SWN-K total scales at admission as well as the GAF, SOFAS and the Strauss-Carpenter Prognostic Scale Sociodemographic and clinical baseline variables were assessed using a standardized documentation system Results 33 patients (12%) fulfilled the symptom severity component of the proposed remission criteria already at baseline Almost no significant differences were found when comparing patients with achieved and failed symptom severity component that would explain the hospitalization of the patients with achieved criteria despite their apparently mild psychopathological symptoms The only explainable difference was that patients with an achieved symptom severity component had received significantly more antipsychotics and had suffered from significantly more life events before admission Conclusion The present results raise the question whether the symptom severity threshold is adequate to identify patients in remission when applied in clinical trials

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wolff, R. Schennach UNSPECIFIED UNSPECIFIED UNSPECIFIED Moller, H. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jager, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seemuller, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Obermeier, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Messer, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Laux, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfeiffer, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Naber, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, L. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaebel, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkotter, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heuser, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemke, M. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruther, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klingberg, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gastpar, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-493917
DOI:	10.1055/s-0030-1262788
Journal or Publication Title:	Pharmacopsychiatry
Volume:	43
Number:	7
Page Range:	S. 245 - 252
Date:	2010
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-0795
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IMPROVEMENT; OUTCOMES; SYSTEM Multiple languages Pharmacology & Pharmacy; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49391