Universität zu Köln

Terschueren, C., Gierer, S., Brillant, C., Paulus, U., Loeffler, M. and Hoffmann, W. (2010). Are patients with Hodgkin lymphoma and high-grade non-Hodgkin lymphoma in clinical therapy optimization protocols representative of these groups of patients in Germany? Ann. Oncol., 21 (10). S. 2045 - 2052. OXFORD: OXFORD UNIV PRESS. ISSN 1569-8041

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Abstract

Background: Improvement of lymphoma therapy is largely driven by clinical therapy optimization protocols (TOPs). It is unclear, however, whether the patients treated in clinical TOP are representative for all patients. Patients and methods: TOP participants were compared with nonstudy patients in a population-based approach. The study included patients with Hodgkin lymphoma (HL) and high-grade non-Hodgkin lymphoma (hgNHL). Incident cases (N = 743) were ascertained in a large population-based epidemiologic survey. Each patient's status with respect to exclusion criteria of the pertinent TOP was abstracted from primary data sources. TOP participants were identified on the basis of the trial databases. Baseline characteristics and risk factor prevalence were compared between nonstudy and TOP patients. Results: Eligible for the respective TOPs were 64.1% of all incident HL patients and 29.6% of all hgNHL patients in the population. Main exclusion criterion was age (HL: 15.2%; hgNHL: 27.4%). Only 71 HL patients (23.0%) and 11 hgNHL patients (3.4%) had actually been enrolled in the respective TOPs. Conclusions: TOP participants do not represent all patients with hgNHL and HL in the population. TOP inclusion criteria caused considerable selection among the participants. Further investigation is required to clarify possible limitations for the application of the outcomes observed in TOP patients for all patients with these diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Terschueren, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gierer, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brillant, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Paulus, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Loeffler, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-494578
DOI:	10.1093/annonc/mdq214
Journal or Publication Title:	Ann. Oncol.
Volume:	21
Number:	10
Page Range:	S. 2045 - 2052
Date:	2010
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1569-8041
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXTENDED-FIELD RADIOTHERAPY; 3-WEEKLY CHOP CHEMOTHERAPY; AGGRESSIVE LYMPHOMAS; ELDERLY-PATIENTS; ONGOING IMPROVEMENT; RANDOMIZED-TRIAL; COPP-ABVD; DISEASE; COPP/ABV/IMEP; ETOPOSIDE Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49457