Universität zu Köln

Velthorst, Eva ORCID: 0000-0002-9240-2909, Nieman, Darien H., Linszen, Don, Becker, Hiske, de Haan, Lieuwe, Dingemans, Peter M., Birchwood, Max ORCID: 0000-0002-7476-0171, Patterson, Paul ORCID: 0000-0003-3310-8635, Salokangas, Raimo K. R., Heinimaa, Markus, Heinz, Andreas ORCID: 0000-0001-5405-9065, Juckel, Georg, von Reventlow, Heinrich Graf, French, Paul, Stevens, Helen, Schultze-Lutter, Frauke, Klosterkoetter, Joachim and Ruhrmann, Stephan ORCID: 0000-0002-6022-2364 (2010). Disability in people clinically at high risk of psychosis. Br. J. Psychiatry, 197 (4). S. 278 - 285. CAMBRIDGE: CAMBRIDGE UNIV PRESS. ISSN 1472-1465

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Abstract

Background Decline in social functioning occurs in individuals who later develop psychosis. Aims To investigate whether baseline differences in disability are present in those who do and those who do not make a transition to psychosis in a group clinically at high risk and whether disability is a risk factor for transition. Method Prospective multicentre, naturalistic field study with an 18-month follow-up period on 245 help-seeking individuals clinically at high risk. Disability was assessed with the Disability Assessment Schedule of the World Health Organization (WHODAS-II). Results At baseline, the transition group displayed significantly greater difficulties in making new friends (z = -3.40, P=0.001), maintaining a friendship (z = -3.00, P = 0.003), dealing with people they do not know (z = -2.28, P = 0.023) and joining community activities (z = -2.0, P = 0.05) compared with the non-transition group. In Cox regression, difficulties in getting along with people significantly contributed to the prediction of transition to psychosis in our sample (beta=0.569, s.e. = 0.184, Wald = 9.548, P = 0.002, hazard ratio (HR) = 1.767, 95% CI 1.238-2.550). Conclusions Certain domains of social disability might contribute to the prediction of psychosis in a sample clinically at high risk.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Velthorst, Eva UNSPECIFIED orcid.org/0000-0002-9240-2909 UNSPECIFIED Nieman, Darien H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Linszen, Don UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Hiske UNSPECIFIED UNSPECIFIED UNSPECIFIED de Haan, Lieuwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Dingemans, Peter M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Birchwood, Max UNSPECIFIED orcid.org/0000-0002-7476-0171 UNSPECIFIED Patterson, Paul UNSPECIFIED orcid.org/0000-0003-3310-8635 UNSPECIFIED Salokangas, Raimo K. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinimaa, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinz, Andreas UNSPECIFIED orcid.org/0000-0001-5405-9065 UNSPECIFIED Juckel, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED von Reventlow, Heinrich Graf UNSPECIFIED UNSPECIFIED UNSPECIFIED French, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Stevens, Helen UNSPECIFIED UNSPECIFIED UNSPECIFIED Schultze-Lutter, Frauke UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhrmann, Stephan UNSPECIFIED orcid.org/0000-0002-6022-2364 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-495173
DOI:	10.1192/bjp.bp.109.075036
Journal or Publication Title:	Br. J. Psychiatry
Volume:	197
Number:	4
Page Range:	S. 278 - 285
Date:	2010
Publisher:	CAMBRIDGE UNIV PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1472-1465
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ULTRA-HIGH-RISK; ASSESSMENT-SCHEDULE-II; SCHIZOPHRENIA; DISORDERS; PREDICTION; INDIVIDUALS; VALIDATION; TRANSITION; DEPRESSION; PRODROME Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49517