Universität zu Köln

Niehoff, A., Kersting, U. G., Helling, S., Dargel, J., Maurer, J., Thevis, M. and Brueggemann, G.-P. (2010). Different mechanical loading protocols influence serum cartilage oligomeric matrix protein levels in young healthy humans. Eur. J. Appl. Physiol., 110 (3). S. 651 - 658. NEW YORK: SPRINGER. ISSN 1439-6327

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Abstract

The purpose of the study was to investigate whether a relationship between the loading mode of physical activity and serum cartilage oligomeric matrix protein (COMP) concentration exists and whether the lymphatic system contributes to COMP release into the serum. Serum COMP levels were determined in healthy male subjects before, after and at 18 further time points within 7 h at four separate experimental days with four different loading interventions. The loading intervention included high impact running exercise, slow but deep knee bends, and lymphatic drainage of 30 min duration, respectively, and a resting protocol. The serum COMP levels were measured using a commercially available quantitative enzyme-linked immunosorbent assay. An increase (p < 0.001) in serum COMP concentration was detected immediately after 30 min running exercise. Slow but deep knee bends did not cause any significant changes in serum COMP levels. Lymphatic drainage also had no effect on the serum COMP concentration. After 30 min of complete rest the serum COMP level was significantly (p = 0.008) reduced. The elevation of COMP serum concentration seems to depend on the loading mode of the physical activity and to reflect the extrusion of COMP fragments from the impact loaded articular cartilage or synovial fluid.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Niehoff, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kersting, U. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Helling, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dargel, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maurer, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thevis, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brueggemann, G.-P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-495408
DOI:	10.1007/s00421-010-1529-0
Journal or Publication Title:	Eur. J. Appl. Physiol.
Volume:	110
Number:	3
Page Range:	S. 651 - 658
Date:	2010
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1439-6327
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CYCLIC HYDROSTATIC-PRESSURE; RHEUMATOID-ARTHRITIS; PROTEOGLYCAN METABOLISM; KNEE OSTEOARTHRITIS; COMP CONCENTRATION; BONE METABOLISM; IN-VIVO; PROGRESSION; EXPLANTS; MARKERS Multiple languages Physiology; Sport Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49540