Universität zu Köln

Kraemer, Jan Alexander, Schmid, Kurt Werner, Dralle, Henning, Dietlein, Markus, Schicha, Harald, Lerch, Hartmut, Gerss, Joachim, Frankewitsch, Thomas, Schober, Otmar and Riemann, Burkhard (2010). Primary tumour size is a prognostic parameter in patients suffering from differentiated thyroid carcinoma with extrathyroidal growth: results of the MSDS trial. Eur. J. Endocrinol., 163 (4). S. 637 - 645. BRISTOL: BIOSCIENTIFICA LTD. ISSN 1479-683X

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Abstract

Objective: The Multicentre Study Differentiated Thyroid Cancer (MSDS) collective represents a well-defined group of patients with thyroid carcinomas with extrathyroidal extension. The aim of the present study was to evaluate the relationship of the primary tumour size with clinicopathological features as well as the outcome of patients with minimum and extensive extrathyroidal growth (pT3b- and pT4a-tumours; UICC 2002/2003, 6th ed). Methods: The tumour diameter was available in 324 out of 351 MSDS patients (244 females, 80 males). Mean age of patients was 47.7 +/- 12.0 years (range, 20.1-69.8 years), and the median follow-up was 6.2 years. The relationship between primary tumour size and the following clinicopathological data was investigated: age, gender, histological tumour type (papillary thyroid carcinomas (PTC) versus follicular thyroid carcinomas (FTC)) and UICC/AJCC TNM classification. In addition, the correlation between primary tumour size and event-free and overall survival was assessed. Results: The FTC of our series were significantly larger than PTC (3.46 vs 1.84 cm; P<0.001). Patients suffering from pT3b-tumours presented with significantly smaller tumour size than those with extensive extrathyroidal growth (pT4a-tumours) (1.9 vs 3.0 cm; P<0.01). All patients with distant metastases suffered from tumours >2 cm. Furthermore, event-free and overall survival were significantly correlated with increasing tumour size (P<0.05). Using multivariate analysis, a pT4a-category and a tumour diameter >2 cm remained independent predictors of survival. Conclusions: In patients suffering from differentiated thyroid carcinoma with extrathyroidal growth (pT3b and pT4a), the tumour size is an independent predictor of event-free and overall survival.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kraemer, Jan Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmid, Kurt Werner UNSPECIFIED UNSPECIFIED UNSPECIFIED Dralle, Henning UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Schicha, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Lerch, Hartmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerss, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Frankewitsch, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schober, Otmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Riemann, Burkhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-495422
DOI:	10.1530/EJE-10-0116
Journal or Publication Title:	Eur. J. Endocrinol.
Volume:	163
Number:	4
Page Range:	S. 637 - 645
Date:	2010
Publisher:	BIOSCIENTIFICA LTD
Place of Publication:	BRISTOL
ISSN:	1479-683X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXTERNAL-BEAM RADIOTHERAPY; SCORING SYSTEM; PAPILLARY; CANCER; MULTICENTER; THERAPY; DIAMETER; OUTCOMES; COHORT Multiple languages Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49542