Universität zu Köln

Li, Shu-Chen ORCID: 0000-0001-8409-5390, Chicherio, Christian, Nyberg, Lars ORCID: 0000-0002-3367-1746, von Oertzen, Timo, Nagel, Irene E., Papenberg, Goran, Sander, Thomas, Heekeren, Hauke R., Lindenberger, Ulman ORCID: 0000-0001-8428-6453 and Baeckman, Lars (2010). Ebbinghaus Revisited: Influences of the BDNF Val66Met Polymorphism on Backward Serial Recall Are Modulated by Human Aging. J. Cogn. Neurosci., 22 (10). S. 2164 - 2174. CAMBRIDGE: MIT PRESS. ISSN 0898-929X

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Abstract

The brain-derived neurotrophic factor (BDNF) plays an important role in activity-dependent synaptic plasticity, which underlies learning and memory. In a sample of 948 younger and older adults, we investigated whether a common Val66Met missense polymorphism (rs6265) in the BDNF gene affects the serial position curve-a fundamental phenomenon of associative memory identified by Hermann Ebbinghaus more than a century ago. We found a BDNF polymorphism effect for backward recall in older adults only, with Met-allele carriers (i.e., individuals with reduced BDNF signaling) recalling fewer items than Val homozygotes. This effect was specific to the primacy and middle portions of the serial position curve, where intralist interference and associative demands are especially high. The poorer performance of older Met-allele carriers reflected transposition errors, whereas no genetic effect was found for omissions. These findings indicate that effects of the BDNF polymorphism on episodic memory are most likely to be observed when the associative and executive demands are high. Furthermore, the findings are in line with the hypothesis that the magnitude of genetic effects on cognition is greater when brain resources are reduced, as is the case in old age.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Li, Shu-Chen UNSPECIFIED orcid.org/0000-0001-8409-5390 UNSPECIFIED Chicherio, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Nyberg, Lars UNSPECIFIED orcid.org/0000-0002-3367-1746 UNSPECIFIED von Oertzen, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Nagel, Irene E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Papenberg, Goran UNSPECIFIED UNSPECIFIED UNSPECIFIED Sander, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Heekeren, Hauke R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lindenberger, Ulman UNSPECIFIED orcid.org/0000-0001-8428-6453 UNSPECIFIED Baeckman, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-495721
DOI:	10.1162/jocn.2009.21374
Journal or Publication Title:	J. Cogn. Neurosci.
Volume:	22
Number:	10
Page Range:	S. 2164 - 2174
Date:	2010
Publisher:	MIT PRESS
Place of Publication:	CAMBRIDGE
ISSN:	0898-929X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEUROTROPHIC FACTOR VAL66MET; SHORT-TERM-MEMORY; WORKING-MEMORY; HIPPOCAMPAL ACTIVITY; FACTOR GENE; LIFE-SPAN; COGNITIVE-ABILITIES; ORDER INFORMATION; EPISODIC MEMORY; BRAIN Multiple languages Neurosciences; Psychology, Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49572