Universität zu Köln

Eggers, Carsten, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Nowak, Dennis A. (2010). Theta burst stimulation over the primary motor cortex does not induce cortical plasticity in Parkinson's disease. J. Neurol., 257 (10). S. 1669 - 1675. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 0340-5354

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Abstract

The purpose of this study was to investigate whether a period of continuous theta burst stimulation (cTBS) induces cortical plasticity and thus improves bradykinesia of the upper limb in Parkinson's disease. In eight patients with Parkinson's disease (two females; mean age: 68.5 +/- A 5 years; disease duration: 4 +/- A 3 years) electrophysiological (motor evoked potentials, contralateral and ipsilateral silent period) and behavioural (Purdue pegboard test, UPDRS motor subscore) parameters were evaluated before (baseline condition) and after a 40-s period of (1) real or (2) sham continuous theta burst stimulation over the primary motor cortex contralateral to the more affected body side off dopaminergic drugs. Compared to baseline, cTBS did change neither measures of cortical excitability nor behavioural measures. cTBS over the primary motor cortex does not impact on cortical excitability or motor function of the upper limb in Parkinson's disease. We interpret these data to reflect impaired cortical plasticity in Parkinson's disease. This study is an important contribution to the knowledge about impaired plasticity in Parkinson's disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Nowak, Dennis A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-495836
DOI:	10.1007/s00415-010-5597-1
Journal or Publication Title:	J. Neurol.
Volume:	257
Number:	10
Page Range:	S. 1669 - 1675
Date:	2010
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	0340-5354
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; LEVODOPA-INDUCED DYSKINESIAS; BRAIN-STIMULATION; SILENT PERIOD; EXCITABILITY; INHIBITION; MODELS Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49583