Universität zu Köln

Lux, Silke, Mirzazade, Shahram, Kuzmanovic, Bojana, Plewan, Thorsten ORCID: 0000-0001-5510-1181, Eickhoff, Simon B. ORCID: 0000-0001-6363-2759, Shah, Nadim J., Floege, Juergen, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Eitner, Frank (2010). Differential activation of memory-relevant brain regions during a dialysis cycle. Kidney Int., 78 (8). S. 794 - 803. NEW YORK: NATURE PUBLISHING GROUP. ISSN 0085-2538

Full text not available from this repository.

Abstract

Cognitive impairment is a common and largely undiagnosed finding in a significant number of dialysis patients. These alterations may result from concomitant cerebrovascular disease, hemodynamic instability, the uremic milieu, or changes induced by the dialysis process. In order to gain further insight into this, we recruited 12 stable chronic hemodialysis patients (without clinical neurological disease) and an age-and gender-matched cohort of 12 control individuals (without renal or neurological problems) in a prospective, single-center study. In order to disentangle the influence of dialysis itself on memory function, each dialysis patient was tested twice: once immediately before dialysis following a long weekend (t1) and again the day after this dialysis (t2). The control individuals were tested in the same time frame. Neuropsychological testing found that the control individuals performed significantly better in verbal learning, motor speed, task switching, verbal comprehension, word fluency, spatial visualization, spatial perception, and reasoning; all independent of the time point. Functional magnetic resonance imaging of the whole brain in seven hemodialysis patients found significantly more bilateral activation of the hippocampus during the verbal working memory task at t2 relative to t1 compared with their seven matched control counterparts. Thus, our study found differential and task-specific activation of memory-relevant brain areas during a dialysis cycle. Kidney International (2010) 78, 794-802; doi: 10.1038/ki.2010.253; published online 28 July 2010

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lux, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED Mirzazade, Shahram UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuzmanovic, Bojana UNSPECIFIED UNSPECIFIED UNSPECIFIED Plewan, Thorsten UNSPECIFIED orcid.org/0000-0001-5510-1181 UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED Shah, Nadim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Floege, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Eitner, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-495938
DOI:	10.1038/ki.2010.253
Journal or Publication Title:	Kidney Int.
Volume:	78
Number:	8
Page Range:	S. 794 - 803
Date:	2010
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	NEW YORK
ISSN:	0085-2538
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC-HEMODIALYSIS PATIENTS; SILENT CEREBRAL INFARCTION; VERBAL WORKING-MEMORY; COGNITIVE FUNCTION; NEUROCOGNITIVE FUNCTION; CYTOARCHITECTONIC MAPS; REGISTRATION; RETRIEVAL; ATTENTION; NETWORK Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49593