Universität zu Köln

Belgardt, Bengt F., Mauer, Jan ORCID: 0000-0002-0189-5876 and Bruening, Jens C. (2010). Novel roles for JNK1 in metabolism. Aging-US, 2 (9). S. 621 - 627. ORCHARD PARK: IMPACT JOURNALS LLC. ISSN 1945-4589

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Abstract

Activation of stress-kinase signaling has recently been recognized as an important pathophysiological mechanism in the development of diet-induced obesity, type 2 diabetes mellitus and other aging-related pathologies. Here, c-Jun N-terminal Kinase (JNK) 1 knockout mice have been shown to exhibit protection from diet-induced obesity, glucose intolerance, and insulin resistance. Nonetheless, the tissue-specific role of JNK1-activation in the development of the metabolic syndrome has been poorly defined so far. Recently, it was demonstrated that JNK1 signaling plays a crucial role in the central nervous system (CNS) and in the pituitary to control systemic glucose and lipid metabolism partially through regulation of hormones involved in growth and energy expenditure.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Belgardt, Bengt F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mauer, Jan UNSPECIFIED orcid.org/0000-0002-0189-5876 UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-496703
DOI:	10.18632/aging.100192
Journal or Publication Title:	Aging-US
Volume:	2
Number:	9
Page Range:	S. 621 - 627
Date:	2010
Publisher:	IMPACT JOURNALS LLC
Place of Publication:	ORCHARD PARK
ISSN:	1945-4589
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOPLASMIC-RETICULUM STRESS; N-TERMINAL KINASE; INDUCED INSULIN-RESISTANCE; REGULATES LIFE-SPAN; GROWTH-HORMONE; CAENORHABDITIS-ELEGANS; TRANSCRIPTION FACTORS; GLUCOSE-PRODUCTION; LEPTIN RESISTANCE; ADIPOSE-TISSUE Multiple languages Cell Biology; Geriatrics & Gerontology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49670