Apoptosis regulation at the mitochondria membrane level - Kölner UniversitätsPublikationsServer

Dadsena, Shashank ORCID: 0000-0002-0227-5900, King, Louise E ORCID: 0000-0003-2453-8887 and Garcia-Saez, Ana J. ORCID: 0000-0002-3894-5945 (2021). Apoptosis regulation at the mitochondria membrane level. Biochim Biophys Acta Biomembr, 12 (1863). p. 183716. Elsevier. Open Access

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DOI:10.1016/j.bbamem.2021.183716

Abstract

Mitochondrial outer membrane permeabilization (MOMP) is a key checkpoint in apoptosis that activates the caspase cascade and irreversibly causes the majority of cells to die. The proteins of the Bcl-2 family are master regulators of apoptosis that form a complex interaction network within the mitochondrial membrane that determines the induction of MOMP. This culminates in the activation of the effector members Bax and Bak, which permeabilize the mitochondrial outer membrane to mediate MOMP. Although the key role of Bax and Bak has been established, many questions remain unresolved regarding molecular mechanisms that control the apoptotic pore. In this review, we discuss the recent progress in our understanding of the regulation of Bax/Bak activity within the mitochondrial membrane.

Item Type:

Journal Article

Creators:

Creators	Email	ORCID	ORCID Put Code
Dadsena, Shashank	UNSPECIFIED	orcid.org/0000-0002-0227-5900	UNSPECIFIED
King, Louise E	UNSPECIFIED	orcid.org/0000-0003-2453-8887	UNSPECIFIED
Garcia-Saez, Ana J.	ana.garcia@uni-koeln.de	orcid.org/0000-0002-3894-5945	UNSPECIFIED