Universität zu Köln

Wagner, Ben Jonathan ORCID: 0000-0002-5401-2512 (2021). Dopaminergic Modulation of Intertemporal Choice. PhD thesis, Universität zu Köln.

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Abstract

The overall goal of the studies presented in this dissertation is to improve our understanding of dopamine (DA)-associated changes in intertemporal preferences. Understanding these DA-mediated relationships is essential to our understanding of the continuous dimensions of human functioning and the promise of the RDoC framework (U.S. Department of Health and Human Services, National Institutes of 2016). Study 1 in this dissertation investigates DAergic modulation of intertemporal choice in healthy adult participants using the DA D2-receptor antagonist haloperidol and state-of-the-art computational approaches to further decompose the decision-process. Study 2 takes behavioral testing beyond the lab into real-life environments and assesses the effects of addiction related environments on intertemporal preferences and model-based reinforcement learning in regular slot machine gamblers. In Study 3 we examine whether patients with Tourette Syndrome show aberrations in intertemporal choice. This is of particular interest because Tourette Syndrome is associated with reward sensitivity and disturbances in DA neurotransmission. In Study 4 we investigate short- and long-term stability of intertemporal preferences as a function of acute and chronic deep brain stimulation in a cohort of Obsessive-Compulsive Disorder patients.

Item Type:	Thesis (PhD thesis)
Creators:	Creators Email ORCID ORCID Put Code Wagner, Ben Jonathan ben.jonathan.wagner@gmail.com orcid.org/0000-0002-5401-2512 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-550705
Date:	17 September 2021
Language:	English
Faculty:	Faculty of Human Sciences
Divisions:	Faculty of Human Sciences > Department Psychologie
Subjects:	Psychology General statistics Life sciences
Uncontrolled Keywords:	Keywords Language dopamine, intertemporal choice, delay discounting, decision-making, computational modeling, cognitive neuroscience, reinforcement learning, model-based control, two step task English
Date of oral exam:	27 January 2022
Referee:	Name Academic Title Peters, Jan Prof. Dr. Stahl, Jutta Prof. Dr.
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/55070