Universität zu Köln

Arroub, Karim, Gessner, Isabel ORCID: 0000-0001-9674-161X, Fischer, Thomas and Mathur, Sanjay (2021). Thermoresponsive Poly (N-Isopropylacrylamide)/Polycaprolacton Nanofibrous Scaffolds for Controlled Release of Antibiotics. Adv. Eng. Mater., 23 (9). WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1527-2648

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Abstract

Smart antibacterial materials capable of releasing antibiotic drugs upon exposure to external triggers are highly desired for various medical applications. Herein, the fabrication of thermosensitive drug-loaded core-shell nanofibers using the electrospinning technique combined with in situ UV photopolymerization is reported on. The electrospinning method is used for shaping the core structure comprising biodegradable polymer polycaprolactone (PCL). The PCL fibers are coated with the temperature-responsive poly-N-isopropylacrylamide (PNIPAM) via a UV photopolymerization process that allows to precisely control the shell thickness as verified by transmission electron microscope (TEM) analysis. The temperature-dependent switchable wettability of prepared core-shell fibers is investigated and visualized though water contact angle measurements below and above the lower critical solution temperature. Loading of the antibiotic drug doxycycline hyclate (Doxy) in the PCL core nanofibers results in drug-encapsulating fiber meshes that allow diffusion of drug molecules through the PNIPAM shell in a temperature-dependent manner. The antibacterial activity is examined using Gram-negative Escherichia coli (E. coli) as well as Gram-positive Staphylococcus aureus (S. aureus) bacteria. The results demonstrate the high suitability of prepared biocompatible electrospun core-shell PCL/PNIPAM nanofibers as carriers for antibiotic drugs with temperature-sensitive release behavior.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Arroub, Karim UNSPECIFIED UNSPECIFIED UNSPECIFIED Gessner, Isabel UNSPECIFIED orcid.org/0000-0001-9674-161X UNSPECIFIED Fischer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathur, Sanjay UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-561581
DOI:	10.1002/adem.202100221
Journal or Publication Title:	Adv. Eng. Mater.
Volume:	23
Number:	9
Date:	2021
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1527-2648
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DRUG-RELEASE; POLY(N-ISOPROPYLACRYLAMIDE); PNIPAM; CYTOTOXICITY; MICROGELS Multiple languages Materials Science, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56158