Universität zu Köln

Li, Panpan, Liu, Hanhan, Shi, Xin and Prokosch, Verena (2021). Hydrogen Sulfide: Novel Endogenous and Exogenous Modulator of Oxidative Stress in Retinal Degeneration Diseases. Molecules, 26 (9). BASEL: MDPI. ISSN 1420-3049

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Abstract

Oxidative stress (OS) damage can cause significant injury to cells, which is related to the occurrence and development of many diseases. This pathological process is considered to be the first step to trigger the death of outer retinal neurons, which is related to the pathology of retinal degenerative diseases. Hydrogen sulfide (H2S) has recently received widespread attention as a physiological signal molecule and gas neuromodulator and plays an important role in regulating OS in eyes. In this article, we reviewed the OS responses and regulatory mechanisms of H2S and its donors as endogenous and exogenous regulators in retinal degenerative diseases. Understanding the relevant mechanisms will help to identify the therapeutic potential of H2S in retinal degenerative diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Li, Panpan UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Hanhan UNSPECIFIED UNSPECIFIED UNSPECIFIED Shi, Xin UNSPECIFIED UNSPECIFIED UNSPECIFIED Prokosch, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-561893
DOI:	10.3390/molecules26092411
Journal or Publication Title:	Molecules
Volume:	26
Number:	9
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1420-3049
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CYSTATHIONINE-BETA-SYNTHASE; INDUCED NEURONAL INJURY; MACULAR DEGENERATION; CARDIOVASCULAR-DISEASE; DEHYDROASCORBIC ACID; GANGLION-CELLS; PHOTOCHEMICAL DAMAGE; PIGMENT EPITHELIUM; PROTECTS NEURONS; ALPHA-SYNUCLEIN Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56189