Universität zu Köln

Mahjoub, Samy and Heidenreich, Axel (2021). Oligometastatic prostate cancer: definition and the role of local and systemic therapy: a narrative review. Transl. Androl. Urol., 10 (7). S. 3167 - 3176. SHATIN: AME PUBL CO. ISSN 2223-4691

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Abstract

The definition of oligometastatic prostate cancer (OMPC) includes a heterogenous group of disease states, mostly defined by the number and site of metastases, which seems to be biologically different to widespread tumors. Evidence suggests a substantial survival benefit for this subgroup of limited metastatic burden which is currently seen as a potentially curable disease and therefore with an increasing interest in the scientific community. As there is still no consensus on the definition of OMPC, commonly used criteria are based on the CHAARTED and LATITUDE trials. The management algorithms for these patients were rapidly changing in the past decade due to recent data with a paradigm shift to a multimodal intensification of the treatment by the availability of combinations of hormonal therapy with taxane-based chemotherapy and androgen-receptor-targeted agents leading to significant improvement of clinical outcomes. In addition, radiotherapy of the primary tumor is associated with significant survival benefit in patients with OMPC establishing a new arm in the multimodal treatment concept. Recent data on metastases directed therapy and cytoreductive prostatectomy showed promising results, while there is still a lack of prospective trials and therefore should be limited to experimental settings. The purpose of this review is to summarize and discuss the existing data on treatment of OMPC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mahjoub, Samy UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-562255
DOI:	10.21037/tau-20-1033
Journal or Publication Title:	Transl. Androl. Urol.
Volume:	10
Number:	7
Page Range:	S. 3167 - 3176
Date:	2021
Publisher:	AME PUBL CO
Place of Publication:	SHATIN
ISSN:	2223-4691
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANDROGEN-DEPRIVATION THERAPY; CYTOREDUCTIVE RADICAL PROSTATECTOMY; STEREOTACTIC BODY RADIOTHERAPY; ACETATE PLUS PREDNISONE; PRIMARY TUMOR; SURVIVAL; MEN; METASTASES; RECURRENCE; DOCETAXEL Multiple languages Andrology; Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56225