Universität zu Köln

Liu, Hongtao, Liu, Hanhan and Prokosch, Verena (2021). The Relationship between Mitochondria and Neurodegeration in the Eye: A Review. Appl. Sci.-Basel, 11 (16). BASEL: MDPI. ISSN 2076-3417

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Abstract

Mitochondria are the energy factories of cells. Mitochondrial dysfunction directly affects the function and morphology of cells. In recent years, growing evidence has shown that mitochondrial dysfunction plays an important role in neurodegenerative diseases. In the eye, some age-related diseases are considered to be neurodegenerative diseases, such as primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD). Here, we review the mechanisms of mitochondrial damage, post-injury repair, and the roles of mitochondria in various tissues of the eye. In the following sections, the potential for treating glaucoma by reducing mitochondrial damage and promoting post-injury repair is also discussed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Liu, Hongtao UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Hanhan UNSPECIFIED UNSPECIFIED UNSPECIFIED Prokosch, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-563819
DOI:	10.3390/app11167385
Journal or Publication Title:	Appl. Sci.-Basel
Volume:	11
Number:	16
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-3417
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RETINAL GANGLION-CELLS; TRABECULAR MESHWORK CELLS; OPTIC-NERVE HEAD; TRIGGERS OPA1 RELEASE; OXIDATIVE STRESS; DNA MUTATIONS; INORGANIC POLYPHOSPHATE; OCULAR HYPERTENSION; EXPERIMENTAL-MODEL; NEURITE OUTGROWTH Multiple languages Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials Science, Multidisciplinary; Physics, Applied Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56381