Universität zu Köln

Suchan, M., Wuerdemann, N., Sharma, S. J. and Klussmann, J. P. (2021). HPV-related oropharyngeal squamous cell carcinoma-Incidence steadily rising. HNO, 69 (7). S. 599 - 609. NEW YORK: SPRINGER. ISSN 1433-0458

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Abstract

The incidence of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is steadily increasing worldwide and has already exceeded cervical cancer rates in the USA. Due to their tumor biology, HPV-positive tumors of the oropharynx, which have been included in the eighth edition of the AJCC/UICC (American Joint Committee on Cancer/Union Internationale Contre le Cancer) Staging Manual since 2018, represent a separate entity. Following biopsy, diagnostic confirmation is performed by immunohistochemical detection of p16 expression, with p16 acting as a surrogate marker. Therapeutically, surgical and radiotherapeutic approaches are considered equivalent in terms of efficacy. With a 5-year overall survival of up to 80%, patients with HPV-positive OPSCC have a better prognosis compared to patients with HPV-negative OPSCC, where survival rates are between 40 and 50%.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Suchan, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wuerdemann, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sharma, S. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klussmann, J. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-565851
DOI:	10.1007/s00106-021-01087-0
Journal or Publication Title:	HNO
Volume:	69
Number:	7
Page Range:	S. 599 - 609
Date:	2021
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-0458
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ORAL HUMAN-PAPILLOMAVIRUS; UNITED-STATES; RECURRENT; HEAD; CANCER; PREVALENCE; INFECTION; SURVIVAL; VACCINATION; POPULATION Multiple languages Otorhinolaryngology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56585