Suchan, M., Wuerdemann, N., Sharma, S. J. and Klussmann, J. P. (2021). HPV-related oropharyngeal squamous cell carcinoma-Incidence steadily rising. HNO, 69 (7). S. 599 - 609. NEW YORK: SPRINGER. ISSN 1433-0458
Full text not available from this repository.Abstract
The incidence of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is steadily increasing worldwide and has already exceeded cervical cancer rates in the USA. Due to their tumor biology, HPV-positive tumors of the oropharynx, which have been included in the eighth edition of the AJCC/UICC (American Joint Committee on Cancer/Union Internationale Contre le Cancer) Staging Manual since 2018, represent a separate entity. Following biopsy, diagnostic confirmation is performed by immunohistochemical detection of p16 expression, with p16 acting as a surrogate marker. Therapeutically, surgical and radiotherapeutic approaches are considered equivalent in terms of efficacy. With a 5-year overall survival of up to 80%, patients with HPV-positive OPSCC have a better prognosis compared to patients with HPV-negative OPSCC, where survival rates are between 40 and 50%.
Item Type: | Journal Article | ||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-565851 | ||||||||||||||||||||
DOI: | 10.1007/s00106-021-01087-0 | ||||||||||||||||||||
Journal or Publication Title: | HNO | ||||||||||||||||||||
Volume: | 69 | ||||||||||||||||||||
Number: | 7 | ||||||||||||||||||||
Page Range: | S. 599 - 609 | ||||||||||||||||||||
Date: | 2021 | ||||||||||||||||||||
Publisher: | SPRINGER | ||||||||||||||||||||
Place of Publication: | NEW YORK | ||||||||||||||||||||
ISSN: | 1433-0458 | ||||||||||||||||||||
Language: | German | ||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/56585 |
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