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da Silva, Paulo F. L. and Schumacher, Bjoern (2021). Principles of the Molecular and Cellular Mechanisms of Aging. J. Invest. Dermatol., 141 (4). S. 951 - 961. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1523-1747

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Abstract

Aging can be defined as a state of progressive functional decline accompanied by an increase in mortality. Time-dependent accumulation of cellular damage, namely lesions and mutations in the DNA and misfolded proteins, impair organellar and cellular function. Ensuing cell fate alterations lead to the accumulation of dysfunctional cells and hamper homeostatic processes, thus limiting regenerative potential; trigger low-grade inflammation; and alter intercellular and intertissue communication. The accumulation of molecular damage together with modifications in the epigenetic landscape, dysregulation of gene expression, and altered endocrine communication, drive the aging process and establish age as the main risk factor for age-associated diseases and multimorbidity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code da Silva, Paulo F. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumacher, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-566081
DOI:	10.1016/j.jid.2020.11.018
Journal or Publication Title:	J. Invest. Dermatol.
Volume:	141
Number:	4
Page Range:	S. 951 - 961
Date:	2021
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1523-1747
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56608