Universität zu Köln

Daverkausen-Fischer, Lea and Proels, Felicitas (2021). Dual topology of co-chaperones at the membrane of the endoplasmic reticulum. Cell Death Discov., 7 (1). LONDON: SPRINGERNATURE. ISSN 2058-7716

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Abstract

Dual topologies of proteins at the ER membrane are known for a variety of proteins allowing the same protein to exert different functions according to the topology adopted. A dual topology of the co-chaperone ERdj4, which resides in the endoplasmic reticulum (ER), was proposed recently, a thesis that we found to align all published data and existing controversies into one whole picture. The aim of this review is to reassess all primary data available in the literature on ER-resident Hsp40 co-chaperones with respect to their topology. After careful and critical analyses of all experimental data published so far, we identified, next to ERdj4, two other co-chaperones, ERdj3 and ERdj6, that also display features of a dual topology at the ER membrane. We assume that during cellular stress subpools of some ER-resident J protein can alter their topology so that these proteins can exert different functions in order to adapt to cellular stress.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Daverkausen-Fischer, Lea UNSPECIFIED UNSPECIFIED UNSPECIFIED Proels, Felicitas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-566230
DOI:	10.1038/s41420-021-00594-x
Journal or Publication Title:	Cell Death Discov.
Volume:	7
Number:	1
Date:	2021
Publisher:	SPRINGERNATURE
Place of Publication:	LONDON
ISSN:	2058-7716
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PKR PROTEIN-KINASE; ER DNAJ HOMOLOG; DISULFIDE REDUCTASE; CELLULAR INHIBITOR; RESIDENT PROTEIN; IN-VITRO; J-DOMAIN; STRESS; ERDJ3; FAMILY Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56623