Universität zu Köln

Feng, Yuan, Prokosch, Verena and Liu, Hanhan (2021). Current Perspective of Hydrogen Sulfide as a Novel Gaseous Modulator of Oxidative Stress in Glaucoma. Antioxidants, 10 (5). BASEL: MDPI. ISSN 2076-3921

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Abstract

Glaucoma is a group of diseases characterized by the progressive loss of retinal ganglion cells and their axons. Elevated intraocular pressure (IOP) is the main clinical manifestation of glaucoma. Despite being in the focus of the studies for decades, the characteristic and the exact pathology of neurodegeneration in glaucoma remains unclear. Oxidative stress is believed to be one of the main risk factors in neurodegeneration, especially its damage to the retinal ganglion cells. Hydrogen sulfide (H2S), the recently recognized gas signaling molecule, plays a pivotal role in the nervous system, vascular system, and immune system. It has also shown properties in regulating oxidative stress through different pathways in vivo. In this review, we summarize the distribution and the properties of H2S within the eye with an emphasis on its role in modulating oxidative stress in glaucoma.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Feng, Yuan UNSPECIFIED UNSPECIFIED UNSPECIFIED Prokosch, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Hanhan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-566745
DOI:	10.3390/antiox10050671
Journal or Publication Title:	Antioxidants
Volume:	10
Number:	5
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-3921
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CYSTATHIONINE BETA-SYNTHASE; RETINAL GANGLION-CELLS; OPEN-ANGLE GLAUCOMA; IRON-SULFUR CLUSTERS; MITOCHONDRIAL-DNA; TRABECULAR MESHWORK; SYMPATHETIC NEUROTRANSMISSION; ENDOGENOUS PRODUCTION; ALZHEIMERS-DISEASE; INHIBITORY-ACTION Multiple languages Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science & Technology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56674