Universität zu Köln

Loreck, Niklas, Geries, Carla, Schrittenlocher, Silvia, Siebelmann, Sebastian, Matthaei, Mario, Bachmann, Bjoern, Hayashi, Takahiko and Cursiefen, Claus (2021). Effect of Anticoagulant Therapy on the Outcome of Descemet Membrane Endothelial Keratoplasty. Cornea, 40 (9). S. 1147 - 1152. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-4798

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Abstract

Purpose: To analyze the effect of anticoagulant therapy (ACT) for systemic diseases on the outcome of Descemet membrane endothelial keratoplasty (DMEK). Methods: Consecutive eyes with Fuchs endothelial dystrophy that underwent DMEK between August 4, 2011, and July 15, 2016, were retrospectively analyzed. Data were obtained from the Cologne DMEK database at the University of Cologne, Germany. Best spectacle-corrected visual acuity (logMAR), endothelial cell density (at baseline and postoperatively up to 12 months), and rebubbling rates were compared between patients receiving ACT (ACT group) and those with no anticoagulant treatment (NCT group). Results: In this study, 329 eyes of 329 patients were included (ACT group n = 97, NCT group n = 232; mean age 69.9 +/- 9.1 years). Bleeding was more common in the ACT group (P < 0.001). Preoperative best spectacle-corrected visual acuity was 0.59 +/- 0.44 and 0.48 +/- 0.35 logMAR for the ACT and NCT groups, respectively, which improved to 0.13 +/- 0.08 and 0.08 +/- 0.16 logMAR, respectively, at 12 months postoperatively. No significant difference in endothelial cell density loss at 12 months was found between the groups (ACT group 36.2% +/- 14.7%, NCT group 38.5% +/- 15.1%; P = 0.467). Rebubbling rate was 19.6% in the ACT group and 28.9% in the NCT group (P = 0.08). Conclusions: Although ACT increases the risk for preoperative and intraoperative bleeding in DMEK, there seems to be no negative effect on DMEK outcome. Thus, it is not advisable to stop ACT for DMEK surgery.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Loreck, Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Geries, Carla UNSPECIFIED UNSPECIFIED UNSPECIFIED Schrittenlocher, Silvia UNSPECIFIED UNSPECIFIED UNSPECIFIED Siebelmann, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Matthaei, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachmann, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED Hayashi, Takahiko UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-568218
DOI:	10.1097/ICO.0000000000002533
Journal or Publication Title:	Cornea
Volume:	40
Number:	9
Page Range:	S. 1147 - 1152
Date:	2021
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-4798
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VITREORETINAL SURGERY; COMPLICATIONS; KERATOPATHY; REJECTION; RISK; DMEK Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56821