Universität zu Köln

Gaunitz, Franziska and Andresen-Streichert, Hilke (2022). Analytical findings in a non-fatal intoxication with the synthetic cannabinoid 5F-ADB (5F-MDMB-PINACA): a case report. Int. J. Legal Med., 136 (2). S. 577 - 590. NEW YORK: SPRINGER. ISSN 1437-1596

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Abstract

The case report centres on analytical findings from a spice sample (mixed with tobacco (as a cigarette) for consumption), and its corresponding plasma sample, smoked by a 31-year-old man who was attended by emergency services following collapse. The man was fully conscious and cooperative during initial medical treatment. Suddenly, he suffered a complete loss of self-control, whereupon the police was notified. The man encountered the police officers when exiting the apartment, at which point he threatened them with clenched fists and reached for a plant bucket in order to strike out in the direction of the officers. At the trial, he described himself as confused and as being completely overwhelmed, having lost self-control, suffered a panic attack and just wanted to get out the situation. Furthermore, he stated that he had no recollection of the incident. He feared death due to palpitations, heart pain, dizziness and repetitive anxiety states. Routine systematic as well as extended toxicological analysis of the plasma sample, taken approximately 2 h after the incident, confirmed the use of cannabis and spice. Plasma concentrations of THC, OH-THC and THC-COOH were 8.0 mu g/L, 4.0 mu g/L and 147 mu g/L, respectively. Furthermore, analysis confirmed uptake of 5F-ADB (5F-MDMB-PINACA) via detection of both 5F-ADB and the 5F-ADB N-(5-OH-pentyl) metabolite. The spice sample additionally contained 5F-MDMB-PICA, which was not detected in the plasma sample. A differentiation between a possible co-use and a recent use of cannabis was not possible. In summary, this case once more underlines the health risks of spice use.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gaunitz, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Andresen-Streichert, Hilke UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-568501
DOI:	10.1007/s00414-021-02717-6
Journal or Publication Title:	Int. J. Legal Med.
Volume:	136
Number:	2
Page Range:	S. 577 - 590
Date:	2022
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1437-1596
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEATH FOLLOWING USE; MDMB-CHMICA; PHARMACOLOGICAL EVALUATION; SOLID TISSUES; AMB-FUBINACA; CONSUMPTION; TOXICITY; IDENTIFICATION; INDAZOLE; INDOLE Multiple languages Medicine, Legal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56850