Universität zu Köln

Seufert, Lisa ORCID: 0000-0003-3931-6152, Benzing, Thomas, Ignarski, Michael ORCID: 0000-0001-6057-7694 and Mueller, Roman-Ulrich (2022). RNA-binding proteins and their role in kidney disease. Nat. Rev. Nephrol., 18 (3). S. 153 - 171. BERLIN: NATURE PORTFOLIO. ISSN 1759-507X

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Abstract

RNA-binding proteins are involved in every stage of the RNA life cycle and have a major impact on cellular biology. Here, the authors discuss current knowledge of RNA-binding proteins, their interactions with RNAs and proteins, their roles in kidney diseases and their potential as novel therapeutic targets. RNA-binding proteins (RBPs) are of fundamental importance for post-transcriptional gene regulation and protein synthesis. They are required for pre-mRNA processing and for RNA transport, degradation and translation into protein, and can regulate every step in the life cycle of their RNA targets. In addition, RBP function can be modulated by RNA binding. RBPs also participate in the formation of ribonucleoprotein complexes that build up macromolecular machineries such as the ribosome and spliceosome. Although most research has focused on mRNA-binding proteins, non-coding RNAs are also regulated and sequestered by RBPs. Functional defects and changes in the expression levels of RBPs have been implicated in numerous diseases, including neurological disorders, muscular atrophy and cancers. RBPs also contribute to a wide spectrum of kidney disorders. For example, human antigen R has been reported to have a renoprotective function in acute kidney injury (AKI) but might also contribute to the development of glomerulosclerosis, tubulointerstitial fibrosis and diabetic kidney disease (DKD), loss of bicaudal C is associated with cystic kidney diseases and Y-box binding protein 1 has been implicated in the pathogenesis of AKI, DKD and glomerular disorders. Increasing data suggest that the modulation of RBPs and their interactions with RNA targets could be promising therapeutic strategies for kidney diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Seufert, Lisa UNSPECIFIED orcid.org/0000-0003-3931-6152 UNSPECIFIED Benzing, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Ignarski, Michael UNSPECIFIED orcid.org/0000-0001-6057-7694 UNSPECIFIED Mueller, Roman-Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-568545
DOI:	10.1038/s41581-021-00497-1
Journal or Publication Title:	Nat. Rev. Nephrol.
Volume:	18
Number:	3
Page Range:	S. 153 - 171
Date:	2022
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	1759-507X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EPITHELIAL-MESENCHYMAL TRANSITION; RENAL-CELL CARCINOMA; PLASMINOGEN-ACTIVATOR INHIBITOR-1; ISCHEMIA-REPERFUSION INJURY; PH-RESPONSIVE STABILIZATION; CARBOXYKINASE MESSENGER-RNA; HUMAN-ANTIGEN R; BICAUDAL-C; NONCODING RNAS; GROWTH-FACTOR Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56854