Universität zu Köln

Schorn, Lara ORCID: 0000-0002-4301-0693, Fienitz, Tim, Berndsen, Kathrin, Kuebler, Norbert R., Holtmann, Henrik and Rothamel, Daniel (2021). The use of solvent-preserved human and bovine cancellous bone blocks for lateral defect augmentation-an experimental controlled study in vivo. Head Face Med., 17 (1). LONDON: BMC. ISSN 1746-160X

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Abstract

Background The aim of this study was to compare new bone formation, resorbed bone matrix, and fibrous enclosed residual bone substitute material in laterally augmented alveolar bone defects using allogeneic, pre-treated and cleaned human bone blocks (tested in dogs, therefore considered to be xenogeneic), and pre-treated and cleaned bovine cancellous bone blocks, both with and without a collagen membrane in order to evaluate their augmentative potential. Methods Thirty-two critical size horizontal defects were prepared in the mandible of 4 adult foxhound dogs (8 per dog, 4 on each side). After 3 months of healing, the defects were laterally augmented in a split-mouth-design with either human (HXB) or bovine solvent-preserved bone blocks (BXB). Afterwards, defects were randomly covered with a bovine collagenous membrane (HXB + M, BXB + M). After a healing interval of 6 months, percentages of new bone formation, resorbed bone matrix, and fibrous enclosed residual bone substitute material were compared. Results Results showed little new bone formation of up to 3.7 % in human bone blocks (HXB 3.7 % +/- 10.2, HXB + M 0.3 %+/- 0.4, BXB, 0.1 % +/- 0.8, BXB + M 2.6 % +/- 3.2, p = > 0.05). Percentages of fibrous encapsulation were higher in human bone blocks than in bovine bone blocks (HXB 71.2 % +/- 8.6, HXB + M 73.71 % +/- 10.6, BXB, 60.5 % +/- 27.4, BXB + M 52.5 % +/- 28.4, p = > 0.05). Resorption rates differed from 44.8 % in bovine bone blocks covered with a membrane to 17.4 % in human bone blocks (HXB 17.4 % +/- 7.4, HXB + M 25.9 % +/- 10.7, BXB, 38.4 % +/- 27.2, BXB + M 44.8 % +/- 29.6, p = > 0.05). The use of additional membranes did not significantly affect results. Conclusions Within its limitations, results of this study suggest that solvent-preserved xenogenic human and bovine bone blocks are not suitable for lateral bone augmentation in dogs. Furthermore, defect coverage with a membrane does not positively affect the outcome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schorn, Lara UNSPECIFIED orcid.org/0000-0002-4301-0693 UNSPECIFIED Fienitz, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Berndsen, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuebler, Norbert R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Holtmann, Henrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Rothamel, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-569904
DOI:	10.1186/s13005-021-00275-1
Journal or Publication Title:	Head Face Med.
Volume:	17
Number:	1
Date:	2021
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1746-160X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AUTOGENOUS BONE; SINUS; RECONSTRUCTION; GRAFTS; REGENERATION; ALLOGRAFT; RIDGES Multiple languages Dentistry, Oral Surgery & Medicine Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/56990