Universität zu Köln

Zeuner, Kirsten E., Knutzen, Arne, Granert, Oliver, Trampenau, Leif, Baumann, Alexander, Wolff, Stephan, Jansen, Olav, van Eimeren, Thilo ORCID: 0000-0002-6951-2325 and Kuhtz-Buschbeck, Johann P. (2021). Never too little: Grip and lift forces following probabilistic weight cues in patients with writer's cramp. Clin. Neurophysiol., 132 (12). S. 2937 - 2948. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-8952

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Abstract

Objective: Planning of voluntary object-related movements requires the estimation of the most probable object properties. We investigated how 14 writer's cramp (WC) patients compared to 14 controls use probabilistic weight cues in a serial grip-lift task. Methods: In every grip-lift trial, an object of either light, medium or heavy weight had to be grasped and lifted after a visual cue gave a probabilistic prediction of the object weights (e.g. 32.5% light, 67.5% medium, 0 % heavy). We determined peak (1) grip force GF, (2) load force LF, (3) grip force rate GFR, (4) load force rate LFR, while we registered brain activity with functional magnetic resonance imaging. Results: In both groups, GFR, LFR and GF increased when a higher probability of heavy weights was announced. When a higher probability of light weights was indicated, controls reduced GFR, LFR and GF, while WC patients did not downscale their forces. There were no inter-group differences in blood oxygenation level dependent activation. Conclusions: WC patients could not utilize the decision range in motor planning and adjust their force in a probabilistic cued fine motor task. Significance: The results support the pathophysiological model of a hyperfunctional dopamine dependent direct basal ganglia pathway in WC. (C) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zeuner, Kirsten E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knutzen, Arne UNSPECIFIED UNSPECIFIED UNSPECIFIED Granert, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Trampenau, Leif UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumann, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolff, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Jansen, Olav UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED orcid.org/0000-0002-6951-2325 UNSPECIFIED Kuhtz-Buschbeck, Johann P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-570119
DOI:	10.1016/j.clinph.2021.09.010
Journal or Publication Title:	Clin. Neurophysiol.
Volume:	132
Number:	12
Page Range:	S. 2937 - 2948
Date:	2021
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-8952
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SENSORY-MOTOR INTEGRATION; FOCAL HAND DYSTONIA; BASAL GANGLIA; OBJECT MANIPULATION; ACTIVATION PATTERNS; TASK; IMPAIRMENT; MEMORY; PATHOPHYSIOLOGY; CONNECTIVITY Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57011