Universität zu Köln

Schaefer, Georg, Bednarova, Nikola, Heidenreich, Axel, Klocker, Helmut and Heidegger, Isabel (2021). KDM5D predicts response to docetaxel chemotherapy in metastatic castration resistant prostate cancer patients. Transl. Androl. Urol., 10 (10). S. 3946 - 3954. SHATIN: AME PUBL CO. ISSN 2223-4691

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Abstract

Background: The administration of docetaxel chemotherapy is one therapeutic option to delay disease progression and increase overall survival in metastatic castration resistant prostate cancer (mCRPC). However, about 15% of patients are primary resistant to chemotherapy and hence would benefit from an alternative mCRPC treatment. Despite intensive research, there are no robust clinical validated biomarkers to predict mCRPC therapy response. Thus, the aim of the study was to determine KDM5D expression in archival radical prostatectomy specimens of patients medicated with docetaxel at time of mCRPC development in order to correlate KMD5D expression with treatment response. Methods: We used in situ hybridization (ISH) (RNA scope 2.5 HD) to determine KDM5D expression in tissue samples of 28 prostate cancer patients. KDM5D status was correlated to chemotherapy response (PSA and radiographic response). Results: Data revealed that KDM5D is significantly overexpressed in tumor cells (P<0.0001) but also in benign cells (P<0.02) of those patients who responded to chemotherapy compared to non-responders. Conclusions: To summarize, KDM5D is a promising novel biomarker predicting response to docetaxel chemotherapy already at the time of localized disease and thus potentially avoiding metastatic biopsies in the mCRPC stage of disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schaefer, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Bednarova, Nikola UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Klocker, Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidegger, Isabel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-570265
DOI:	10.21037/tau-20-1084
Journal or Publication Title:	Transl. Androl. Urol.
Volume:	10
Number:	10
Page Range:	S. 3946 - 3954
Date:	2021
Publisher:	AME PUBL CO
Place of Publication:	SHATIN
ISSN:	2223-4691
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RECEPTOR Multiple languages Andrology; Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/57026